Chemistry:17α-Bromoprogesterone
From HandWiki
Short description: Chemical compound
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| Other names | 17α-BP; 17α-Bromopregn-4-ene-3,20-dione |
| Drug class | Progestogen; Progestin |
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| Formula | C21H29BrO2 |
| Molar mass | 393.365 g·mol−1 |
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17α-Bromoprogesterone (17α-BP) is a progestin which was first described in 1957 and was never marketed.[1][2][3][4] It is about twice as potent as progesterone in terms of progestogenic activity in animal bioassays.[1] 17α-BP is a parent compound of haloprogesterone (6α-fluoro-17α-bromoprogesterone) and 6α-methyl-17α-bromoprogesterone.[5]
See also
References
- ↑ 1.0 1.1 "Steroids and related products. X. 17 alpha-Bromoprogesterone, a new potent gestogen". Canadian Journal of Biochemistry and Physiology 35 (11): 1047–1055. November 1957. doi:10.1139/o57-120. PMID 13479803.
- ↑ "Molecular interactions of progesterone analogues with rabbit uterine cytoplasmic receptor". The Journal of Biological Chemistry 257 (22): 13359–13366. November 1982. doi:10.1016/S0021-9258(18)33456-2. PMID 7142152.
- ↑ "MTD calculations on quantitative structure-activity relationships of steroids binding to the progesterone receptor". Zeitschrift für Naturforschung C 42 (7–8): 935–940. 1987. doi:10.1515/znc-1987-7-834. PMID 2961153.
- ↑ "Structure-activity Relations in Gestagenic Steroids by the MTD Method. The Case of Hard Molecules and Soft Receptors". Quantitative Structure-Activity Relationships 11 (1): 23–28. 1992. doi:10.1002/qsar.19920110104. ISSN 0931-8771.
- ↑ The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. 14 November 2014. pp. 179, 620. ISBN 978-1-4757-2085-3. https://books.google.com/books?id=0vXTBwAAQBAJ&pg=PA179.
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