Chemistry:Besonprodil
From HandWiki
Short description: Chemical compound
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| Other names | CI-1041 |
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| Formula | C21H23FN2O3S |
| Molar mass | 402.48 g·mol−1 |
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Besonprodil (CI-1041) is a drug which acts as an NMDA antagonist, selective for the NR2B subunit.[1][2] It is under development as a supplemental medication for Parkinson's disease, and has been shown in animals to be effective in counteracting the dyskinesias associated with long-term treatment with levodopa and related drugs.[3][4][5][6][7]
References
- ↑ "NR2B containing NMDA receptor dependent windup of single spinal neurons". Neuropharmacology 46 (1): 23–30. January 2004. doi:10.1016/S0028-3908(03)00339-3. PMID 14654094.
- ↑ "The effect of CGX-1007 and CI-1041, novel NMDA receptor antagonists, on kindling acquisition and expression". Epilepsy Research 59 (1): 1–12. March 2004. doi:10.1016/j.eplepsyres.2003.12.010. PMID 15135162.
- ↑ "Prevention of levodopa-induced dyskinesias by a selective NR1A/2B N-methyl-D-aspartate receptor antagonist in parkinsonian monkeys: implication of preproenkephalin". Movement Disorders 21 (1): 9–17. January 2006. doi:10.1002/mds.20654. PMID 16127720.
- ↑ "Prevention of dyskinesia by an NMDA receptor antagonist in MPTP monkeys: effect on adenosine A2A receptors". Synapse (New York, N.Y.) 60 (3): 239–50. September 2006. doi:10.1002/syn.20295. PMID 16739115.
- ↑ "Implication of NMDA receptors in the antidyskinetic activity of cabergoline, CI-1041, and Ro 61-8048 in MPTP monkeys with levodopa-induced dyskinesias". Journal of Molecular Neuroscience 38 (2): 128–42. June 2009. doi:10.1007/s12031-008-9137-8. PMID 18704766.
- ↑ "Effect of non-dopaminergic drug treatment on Levodopa induced dyskinesias in MPTP monkeys: common implication of striatal neuropeptides". Neuropharmacology 58 (1): 286–96. January 2010. doi:10.1016/j.neuropharm.2009.06.030. PMID 19576910.
- ↑ "Changes of AMPA receptors in MPTP monkeys with levodopa-induced dyskinesias". Neuroscience 167 (4): 1160–7. June 2010. doi:10.1016/j.neuroscience.2010.03.022. PMID 20303391.
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