Chemistry:AP-7 (drug)
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| Preferred IUPAC name
2-Amino-7-phosphonoheptanoic acid | |
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| Properties | |
| C7H16NO5P | |
| Molar mass | 225.179 g/mol |
| Density | 1.39 g/mL |
| Boiling point | 480.1 °C (896.2 °F; 753.2 K) |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
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AP-7 is a selective NMDA receptor (NMDAR) antagonist that competitively inhibits the glutamate binding site and thus activation of NMDAR. It has anticonvulsant effects.[1]
AP-7 functions specifically as a NMDA recognition site blocker, in contrast with 7-chlorokynurenate, which acts as a glycine site modulation blocker.[2]
Animal studies
AP-7 injected directly into the dorsal periaqueductal grey (DPAG) of rats produced an anxiolytic effect, whereas direct injection outside of the DPAG did not elicit anxiolytic effects. This suggests that a portion of systemically taken NMDA antagonist's anxiolytic effects comes from the DPAG region of the brain, at least in rats.[3]
The DPAG of the brain is thought to deal with fear-like defensive behavior via NMDA and glycine B receptors.[4] These excitatory glutamate receptors work with the inhibitory GABA receptors to achieve equilibrium in the DPAG of the brain.[5]
AP-7 has been known to cause muscle rigidity and catalepsy in rats following bilateral microinjections (0.02-0.5 nmol) into the globus pallidus and ventral-posterior portions of the caudate-putamen.[6]
The optically pure D-(−)-2-amino-7-phosphonoheptanoic acid [D-AP7], has also been examined. In groups of hypoxia-treated rats, D-AP7 enhanced motility, exhibited anxiogenic-like effect and impaired consolidation in passive avoidance. Both AP-7 and D-AP7 function as potent, specific antagonists of the NMDA receptor.[7]
See also
- APV (drug)
References
- ↑ "Anti-epileptic effects of focal micro-injection of excitatory amino acid antagonists". J. Neural Transm. 72 (3): 191–200. 1988. doi:10.1007/BF01243419. PMID 3047315.
- ↑ Guillemin GJ (April 2012). "Quinolinic acid, the inescapable neurotoxin". FEBS J. 279 (8): 1356–65. doi:10.1111/j.1742-4658.2012.08485.x. PMID 22248144.
- ↑ "Anxiolytic effect in the elevated plus-maze of the NMDA receptor antagonist AP7 microinjected into the dorsal periaqueductal grey". Psychopharmacology 103 (1): 91–4. 1991. doi:10.1007/BF02244080. PMID 1672463.
- ↑ "Modulation of defensive behavior by periaqueductal gray NMDA/glycine-B receptor". Neurosci Biobehav Rev 25 (7–8): 697–709. December 2001. doi:10.1016/S0149-7634(01)00059-8. PMID 11801295.
- ↑ "The effect of baclofen and AP-7 on selected behavior in rats". Pharmacol. Biochem. Behav. 59 (3): 685–9. March 1998. doi:10.1016/S0091-3057(97)00462-0. PMID 9512072.
- ↑ "Blockade of excitatory neurotransmission in the globus pallidus induces rigidity and akinesia in the rat: implications for excitatory neurotransmission in pathogenesis of Parkinson's diseases". Brain Res. 512 (1): 125–31. March 1990. doi:10.1016/0006-8993(90)91180-O. PMID 2159826.
- ↑ "Behavioral effects of D-AP7 in rats subjected to experimental hypoxia". Pol J Pharmacol 55 (3): 337–44. 2003. PMID 14506312. http://rabbit.if-pan.krakow.pl/pjp/pdf/2003/3_337.pdf.
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