Chemistry:S-18986
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Short description: Chemical compound
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| Formula | C10H12N2O2S |
| Molar mass | 224.28 g·mol−1 |
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S-18986 is a positive allosteric modulator of the AMPA receptor related to cyclothiazide. It has nootropic and neuroprotective effects in animal studies, and induces both production of BDNF and AMPA-mediated release of noradrenaline and acetylcholine in the hippocampus and frontal cortex of the brain.[1][2][3][4][5][6][7][8][9][10]
See also
References
- ↑ "(S)-2,3-dihydro-[3,4]cyclopentano-1,2,4-benzothiadiazine-1,1-dioxide: (S18986-1) a positive modulator of AMPA receptors enhances (S)-AMPA-mediated [3H]noradrenaline release from rat hippocampal and frontal cortex slices". European Journal of Pharmacology 401 (2): 145–53. August 2000. doi:10.1016/S0014-2999(00)00433-7. PMID 10924919.
- ↑ "Effects of S 18986-1, a novel cognitive enhancer, on memory performances in an object recognition task in rats". European Journal of Pharmacology 401 (2): 205–12. August 2000. doi:10.1016/S0014-2999(00)00429-5. PMID 10924928.
- ↑ "Positive allosteric modulators of AMPA receptors are neuroprotective against lesions induced by an NMDA agonist in neonatal mouse brain". Brain Research 970 (1–2): 221–5. April 2003. doi:10.1016/S0006-8993(03)02357-6. PMID 12706264.
- ↑ "S 18986, a positive modulator of AMPA receptors with cognition-enhancing properties, increases ACh release in the hippocampus of young and aged rat". Neuroscience Letters 361 (1–3): 120–3. May 2004. doi:10.1016/j.neulet.2003.12.061. PMID 15135908.
- ↑ "Neuropharmacokinetics of a new alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) modulator, S18986 [(S)-2,3-dihydro-[3,4]cyclopentano-1,2,4-benzothiadiazine-1,1-dioxide], in the rat". Drug Metabolism and Disposition 33 (8): 1137–43. August 2005. doi:10.1124/dmd.105.004424. PMID 15860654.
- ↑ "Improvement of episodic contextual memory by S 18986 in middle-aged mice: comparison with donepezil". Psychopharmacology 193 (1): 63–73. July 2007. doi:10.1007/s00213-007-0765-4. PMID 17384936.
- ↑ "The AMPA modulator S 18986 improves declarative and working memory performances in aged mice". Behavioural Pharmacology 19 (3): 235–44. May 2008. doi:10.1097/FBP.0b013e3282feb0c1. PMID 18469541.
- ↑ "Effects of the AMPA receptor modulator S 18986 on measures of cognition and oxidative stress in aged rats". Psychopharmacology 202 (1–3): 225–35. January 2009. doi:10.1007/s00213-008-1301-x. PMID 18762915.
- ↑ "GAP-43 is essential for the neurotrophic effects of BDNF and positive AMPA receptor modulator S18986". Cell Death and Differentiation 16 (4): 624–37. April 2009. doi:10.1038/cdd.2008.188. PMID 19136940.
- ↑ "The AMPA receptor positive allosteric modulator, S18986, is neuroprotective against neonatal excitotoxic and inflammatory brain damage through BDNF synthesis". Neuropharmacology 57 (3): 277–86. September 2009. doi:10.1016/j.neuropharm.2009.05.010. PMID 19501111.
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