Chemistry:Selurampanel
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Short description: Chemical compound
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| Formula | C16H19N5O4S |
| Molar mass | 377.42 g·mol−1 |
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Selurampanel (INN, code name BGG492) is a drug closely related to the quinoxalinedione series which acts as a competitive antagonist of the AMPA and kainate receptors and, as of 2015, is being investigated in clinical trials by Novartis for the treatment of epilepsy.[1][2][3] It has also been studied in the acute treatment of migraine, and was found to produce some pain relief, but with a relatively high rate of side effects.[4]
References
- ↑ "BGG492 (selurampanel), an AMPA/kainate receptor antagonist drug for epilepsy". Expert Opinion on Investigational Drugs 23 (1): 107–113. January 2014. doi:10.1517/13543784.2014.848854. PMID 24147649.
- ↑ "Novel Molecular Targets for Drug-Treatment of Epilepsy". Epilepsy Towards the Next Decade. Contemporary Clinical Neuroscience. 2015. pp. 183–199. doi:10.1007/978-3-319-12283-0_10. ISBN 978-3-319-12282-3.
- ↑ "The AMPA receptor as a therapeutic target in epilepsy: preclinical and clinical evidence". Journal of Receptor, Ligand and Channel Research: 39. 2014. doi:10.2147/JRLCR.S51475. ISSN 1178-699X. https://www.dovepress.com/getfile.php?fileID=21656.
- ↑ "Randomized, multicenter trial to assess the efficacy, safety and tolerability of a single dose of a novel AMPA receptor antagonist BGG492 for the treatment of acute migraine attacks". Cephalalgia 34 (2): 103–113. February 2014. doi:10.1177/0333102413499648. PMID 23963355.
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