Chemistry:Delucemine
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Short description: Chemical compound
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| Formula | C16H17F2N |
| Molar mass | 261.316 g·mol−1 |
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Delucemine (NPS-1506) is a drug which acts as an NMDA antagonist and a serotonin reuptake inhibitor, and has neuroprotective effects.[1][2] It was originally investigated for the treatment of stroke and in 2004 was studied as a potential antidepressant.[3][4][5]
Origin
The basic structure of Delucemine was based on argiotoxin 636, a NMDA antagonist isolated from the venom of the Araneid Argiope aurantia.[6][7][8]
See also
References
- ↑ "NPS 1506, a novel NMDA receptor antagonist and neuroprotectant. Review of preclinical and clinical studies". Annals of the New York Academy of Sciences 890 (1): 450–7. December 1999. doi:10.1111/j.1749-6632.1999.tb08023.x. PMID 10668449. Bibcode: 1999NYASA.890..450M.
- ↑ "NPS 1506 attenuates cognitive dysfunction and hippocampal neuron death following brain trauma in the rat". Experimental Neurology 166 (2): 442–9. December 2000. doi:10.1006/exnr.2000.7513. PMID 11085909.
- ↑ "NPS Pharmaceuticals Inc, Form 10-Q, Quarterly Report, Filing Date May 17, 2004". secdatabase.com. http://edgar.secdatabase.com/173/119312504090111/filing-main.htm.
- ↑ Pyke R, Ceci A, "Pharmaceutical compositions for the treatment and/or prevention of depression", CA patent 2599721
- ↑ Ichinose F, Marutani E, Kida K, "Compositions and methods to treat neurodegenerative diseases", WO patent 2014015047
- ↑ Nentwig, Wolfgang (2013-02-15). Spider Ecophysiology. Springer Science & Business Media. ISBN 9783642339899. https://books.google.com/books?id=sur9JSvSOX0C.
- ↑ "Spider Venom Components as Drug Candidates". Spider Ecophysiology. February 2013. pp. 491–503. doi:10.1007/978-3-642-33989-9_37. ISBN 978-3-642-33988-2.
- ↑ "Neuroactive compounds obtained from arthropod venoms as new therapeutic platforms for the treatment of neurological disorders". The Journal of Venomous Animals and Toxins Including Tropical Diseases 21 (31): 31. August 2015. doi:10.1186/s40409-015-0031-x. PMID 26257776.
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