Chemistry:Sabeluzole
From HandWiki
Short description: Chemical compound
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| Formula | C22H26FN3O2S |
| Molar mass | 415.53 g·mol−1 |
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Sabeluzole (R-58,735) is a nootropic and neuroprotective drug which was originally developed for the treatment of Alzheimer's disease,[1][2] and has subsequently been researched for other applications such as sleep apnoea.[3] It acts primarily as an NMDA antagonist,[4] but other mechanisms of action may also be important.[5][6]
See also
References
- ↑ "The effect of R 58 735 (Sabeluzole) on memory functions in healthy elderly volunteers". Psychopharmacology 94 (1): 52–7. 1988. doi:10.1007/BF00735880. PMID 3126527.
- ↑ "Treatment of Alzheimer's disease with sabeluzole: functional and structural correlates". Clinical Neuropharmacology 20 (4): 338–45. August 1997. doi:10.1097/00002826-199708000-00005. PMID 9260731.
- ↑ "A double-blind, randomized trial of sabeluzole--a putative glutamate antagonist--in obstructive sleep apnea". Sleep 19 (4): 287–9. May 1996. doi:10.1093/sleep/19.4.287. PMID 8776785.
- ↑ "Chronic sabeluzole treatment of cultured rat cerebellar granule cells reduces N-methyl-D-aspartate-induced inward current". European Journal of Pharmacology 232 (1): 131–4. February 1993. doi:10.1016/0014-2999(93)90738-4. PMID 8458392.
- ↑ "Sabeluzole stabilizes the neuronal cytoskeleton". Neurobiology of Aging 17 (4): 573–81. 1996. doi:10.1016/0197-4580(96)00067-x. PMID 8832632.
- ↑ "Priming of cultured neurons with sabeluzole results in long-lasting inhibition of neurotoxin-induced tau expression and cell death". Synapse 26 (2): 95–103. June 1997. doi:10.1002/(SICI)1098-2396(199706)26:2<95::AID-SYN1>3.0.CO;2-8. PMID 9131769. https://iris.unibs.it/bitstream/11379/164175/1/Synapse%201997.pdf.
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