Chemistry:Lanicemine
From HandWiki
Short description: Chemical compound
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| Formula | C13H14N2 |
| Molar mass | 198.269 g·mol−1 |
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Lanicemine (AZD6765) is a low-trapping NMDA receptor antagonist that was under development by AstraZeneca for the management of severe and treatment-resistant depression.[1][2] Lanicemine differs from ketamine in that it is a low-trapping NMDA receptor antagonist, showing similar rapid-acting antidepressant effects to ketamine in clinical trials but with little or no psychotomimetic side effects.[3] However, lanicemine did not meet study endpoints, and its development was terminated by AstraZeneca in 2013.[4]
See also
- 4-Chlorokynurenine
- AD-1211
- Apimostinel
- CERC-301
- Diphenidine
- Ephenidine
- Esketamine
- Lefetamine
- Memantine
- Methoxphenidine
- MT-45
- Rapastinel
References
- ↑ "Lanicemine" (in en). AdisInsight. http://adisinsight.springer.com/drugs/800005269.
- ↑ "New targets for rapid antidepressant action". Progress in Neurobiology 152: 21–37. May 2017. doi:10.1016/j.pneurobio.2015.12.001. PMID 26724279.
- ↑ "A randomized trial of a low-trapping nonselective N-methyl-D-aspartate channel blocker in major depression". Biological Psychiatry 74 (4): 257–64. August 2013. doi:10.1016/j.biopsych.2012.10.019. PMID 23206319.
- ↑ Flowers, Sophie. "Return to growth: AstraZeneca's CEO Pascal Soriot says 2013 was year of "momentum" for the company". http://www.thepharmaletter.com/article/return-to-growth-astrazeneca-s-ceo-pascal-soriot-says-2013-was-year-of-momentum-for-the-company.
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