Chemistry:LY-235959
From HandWiki
Short description: Chemical compound
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| Formula | C11H20NO5P |
| Molar mass | 277.257 g·mol−1 |
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LY-235959 is a competitive antagonist at the NMDA receptor.[1] It has analgesic and neuroprotective effects and causes hypothermia in animal models,[2] as well as reducing the development of tolerance to morphine and altering the reinforcing effects of cocaine.[3][4][5][6][7]
References
- ↑ "N-methyl-D-aspartate receptor antagonists potentiate the antinociceptive effects of morphine in squirrel monkeys". The Journal of Pharmacology and Experimental Therapeutics 298 (1): 288–97. July 2001. PMID 11408554.
- ↑ "N-methyl-D-aspartate antagonists and WIN 55212-2 [4,5-dihydro-2-methyl-4(4-morpholinylmethyl)-1-(1-naphthalenyl-carbonyl)-6H-pyrrolo[3,2,1-i,j]quinolin-6-one], a cannabinoid agonist, interact to produce synergistic hypothermia". The Journal of Pharmacology and Experimental Therapeutics 303 (1): 395–402. October 2002. doi:10.1124/jpet.102.037473. PMID 12235276.
- ↑ "Effects of the competitive N-methyl-D-aspartate receptor antagonist, LY235959 [(-)-6-phosphonomethyl-deca-hydroisoquinoline-3-carboxylic acid], on responding for cocaine under both fixed and progressive ratio schedules of reinforcement". The Journal of Pharmacology and Experimental Therapeutics 315 (1): 449–57. October 2005. doi:10.1124/jpet.105.086355. PMID 16024734.
- ↑ "Continuous exposure to the competitive N-methyl-D: -aspartate receptor antagonist, LY235959, facilitates escalation of cocaine consumption in Sprague-Dawley rats". Psychopharmacology 191 (2): 341–51. April 2007. doi:10.1007/s00213-006-0661-3. PMID 17225167.
- ↑ "Attenuation of morphine antinociceptive tolerance by a CB(1) receptor agonist and an NMDA receptor antagonist: Interactive effects". Neuropharmacology 58 (2): 544–50. February 2010. doi:10.1016/j.neuropharm.2009.08.005. PMID 19699755.
- ↑ "Opioid antinociception, tolerance and dependence: interactions with the N-methyl-D-aspartate system in mice". Behavioural Pharmacology 22 (5–6): 540–7. September 2011. doi:10.1097/FBP.0b013e328348ed08. PMID 21712708.
- ↑ "The selective and competitive N-methyl-D-aspartate receptor antagonist, (-)-6-phosphonomethyl-deca-hydroisoquinoline-3-carboxylic acid, prevents synaptic toxicity induced by amyloid-β in mice". Neuroscience 192: 631–41. September 2011. doi:10.1016/j.neuroscience.2011.06.038. PMID 21756976.
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