Chemistry:ORG-26576
From HandWiki
Short description: Ampakine
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| Formula | C11H12N2O2 |
| Molar mass | 204.229 g·mol−1 |
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ORG-26576 is an ampakine originally developed by Cortex Pharmaceuticals and then licensed to Organon International for development. In animal studies it has been shown to effectively potentiate AMPA receptor function, leading to increased BDNF release and enhanced neuronal differentiation and survival, as well as producing nootropic effects in standardised assays.[1][2][3][4][5][6] Development as an antidepressant has been halted due to a failed Phase II trial for major depressive disorder.[7]
See also
References
- ↑ "Regionally selective and dose-dependent effects of the ampakines Org 26576 and Org 24448 on local cerebral glucose utilisation in the mouse as assessed by 14C-2-deoxyglucose autoradiography". Neuropharmacology 49 (2): 254–64. August 2005. doi:10.1016/j.neuropharm.2005.03.011. PMID 15993447.
- ↑ "Chronic treatment with AMPA receptor potentiator Org 26576 increases neuronal cell proliferation and survival in adult rodent hippocampus". Psychopharmacology 206 (2): 215–22. October 2009. doi:10.1007/s00213-009-1598-0. PMID 19603152.
- ↑ "The ampakine, Org 26576, bolsters early spatial reference learning and retrieval in the Morris water maze: a subchronic, dose-ranging study in rats". Behavioural Pharmacology 20 (7): 662–7. October 2009. doi:10.1097/FBP.0b013e328331ba1b. PMID 19741506.
- ↑ "Translational PK-PD modelling of molecular target modulation for the AMPA receptor positive allosteric modulator Org 26576". Psychopharmacology 218 (4): 713–24. December 2011. doi:10.1007/s00213-011-2365-6. PMID 21647578.
- ↑ "Differential effects of AMPA receptor potentiators and glycine reuptake inhibitors on antipsychotic efficacy and prefrontal glutamatergic transmission". Psychopharmacology 221 (1): 115–31. May 2012. doi:10.1007/s00213-011-2554-3. PMID 22068461.
- ↑ "The AMPA receptor potentiator Org 26576 modulates stress-induced transcription of BDNF isoforms in rat hippocampus". Pharmacological Research 65 (2): 176–81. February 2012. doi:10.1016/j.phrs.2011.10.004. PMID 22079295.
- ↑ "New targets for rapid antidepressant action". Progress in Neurobiology 152: 21–37. May 2017. doi:10.1016/j.pneurobio.2015.12.001. PMID 26724279.
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