Chemistry:L-701324
L-701324 is an antagonist of the NMDA receptor. It appears to have activity in animal models of depression.
Pharmacology
L-701324 appears to be an antagonist of the NMDA receptor and acts at the glycine binding site.[1] This means that it prevents the receptor from activating by blocking the binding of glycine, a required co-agonist in addition to glutamate.
Potential use as an antidepressant
L-701324 exhibited antidepressant behavior in mice by reducing depression-like behavior caused by the forced swimming test, the tail suspension test, and the chronic unpredictable mild stress model.[2]
In another animal study, a combination of an adenosine receptor antagonist, such as caffeine, with an NMDA receptor antagonist, such as L-701324, showed a synergistic effect that might have use as an antidepressant.[3]
References
- ↑ "Electrophysiological characterisation of the antagonist properties of two novel NMDA receptor glycine site antagonists, L-695,902 and L-701,324". Neuropharmacology 35 (11): 1573–1581. 1996. doi:10.1016/s0028-3908(96)00141-4. PMID 9025105.
- ↑ "Antidepressant-like activity of L-701324 in mice: A behavioral and neurobiological characterization". Behavioural Brain Research 399. February 2021. doi:10.1016/j.bbr.2020.113038. PMID 33276033.
- ↑ "Synergistic antidepressant-like effect of the joint administration of caffeine and NMDA receptor ligands in the forced swim test in mice". Journal of Neural Transmission 123 (4): 463–472. April 2016. doi:10.1007/s00702-015-1467-4. PMID 26510772.
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