Chemistry:PEPA (drug)
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Short description: Chemical compound
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| Other names | PEPA |
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| Formula | C16H16F2N2O4S2 |
| Molar mass | 402.43 g·mol−1 |
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PEPA is a sulfonamide AMPA receptor positive allosteric modulator,[1][2] which is up to 100 times more potent than aniracetam in vitro.[3] It produces memory-enhancing effects in rats when administered intravenously.[4]
See also
References
- ↑ "Pharmacological detection of AMPA receptor heterogeneity by use of two allosteric potentiators in rat hippocampal cultures". British Journal of Pharmacology 123 (7): 1294–303. April 1998. doi:10.1038/sj.bjp.0701707. PMID 9579722.
- ↑ "A desensitization-selective potentiator of AMPA-type glutamate receptors". British Journal of Pharmacology 136 (7): 1033–41. August 2002. doi:10.1038/sj.bjp.0704804. PMID 12145103.
- ↑ "A novel allosteric potentiator of AMPA receptors: 4--2-(phenylsulfonylamino)ethylthio--2,6-difluoro-phenoxyaceta mide". The Journal of Neuroscience 17 (15): 5760–71. August 1997. doi:10.1523/JNEUROSCI.17-15-05760.1997. PMID 9221774.
- ↑ "The AMPA receptor allosteric potentiator PEPA ameliorates post-ischemic memory impairment". NeuroReport 12 (13): 2947–50. September 2001. doi:10.1097/00001756-200109170-00038. PMID 11588608.
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