Chemistry:A-NK
From HandWiki
A-NK, or alkyne-norketamine, is a designer drug from the arylcyclohexylamine family. It is derived from norketamine, a major metabolite of ketamine. It acts as a non-competitive NMDA antagonist, with comparable effects to ketamine.[1]
Pharmacology
Pharmacodynamics
A-NK acts as an antagonist at the PCP site of NMDA receptors. The effects depend on the presence of a protonable nitrogen atom, with A-NK-amide showing substantially lower activity at NMDA receptors. The potency of A-NK at NMDA receptors has been shown to be roughly 4 times lower than ketamine.[1]
See also
References
- ↑ 1.0 1.1 "A Clickable Analogue of Ketamine Retains NMDA Receptor Activity, Psychoactivity, and Accumulates in Neurons". Scientific Reports 6. December 2016. doi:10.1038/srep38808. PMID 27982047. Bibcode: 2016NatSR...638808E.
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