Chemistry:Quinpirole
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| Preferred IUPAC name
(4aR,8aR)-5-Propyl-4,4a,5,6,7,8,8a,9-octahydro-1H-pyrazolo[3,4-g]quinoline | |
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3D model (JSmol)
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| MeSH | D019257 |
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| Properties | |
| C13H21N3 | |
| Molar mass | 219.33 g/mol |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
 verify (what is   ?)
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Quinpirole is a psychoactive drug and research chemical which acts as a selective D2 and D3 receptor agonist. It is used in scientific research.[1][2][3] Quinpirole has been shown to increase locomotion and sniffing behavior in mice treated with it. At least one study has found that quinpirole induces compulsive behavior symptomatic of obsessive compulsive disorder in rats.[4] Another study in rats show that quinpirole produces significant THC-like effects when metabolic degradation of anandamide is inhibited, supporting the hypothesis that these effects of quinpirole are mediated by cannabinoid CB1 receptors.[5] Quinpirole may also reduce relapse in adolescent rat models of cocaine addiction.[6]
Experiments in flies found quinpirole may have neuroprotective effects against Parkinson's disease-like pathology.[7] Moreover, in primary neuronal cultures it also reduces the rate of firing in dopaminergic neurons.[7]
See also
References
- ↑ "Biphasic effect of D-2 agonist quinpirole on locomotion and movements". European Journal of Pharmacology 161 (2–3): 151–7. February 1989. doi:10.1016/0014-2999(89)90837-6. PMID 2566488.
- ↑ "Behavioral profile of quinpirole in agonistic encounters between male mice". Methods and Findings in Experimental and Clinical Pharmacology 21 (7): 477–80. September 1999. doi:10.1358/mf.1999.21.7.550110. PMID 10544391.
- ↑ "Repeated quinpirole treatment increases cAMP-dependent protein kinase activity and CREB phosphorylation in nucleus accumbens and reverses quinpirole-induced sensorimotor gating deficits in rats". Neuropsychopharmacology 29 (10): 1823–30. October 2004. doi:10.1038/sj.npp.1300483. PMID 15138441.
- ↑ Szechtman, Henry; Sulis, William; Eilam, David (1998). "Quinpirole induces compulsive checking behavior in rats: A potential animal model of obsessive-compulsive disorder (OCD)". Behavioral Neuroscience 112 (6): 1475–85. doi:10.1037/0735-7044.112.6.1475. PMID 9926830.
- ↑ Solinas, Marcello; Tanda, Gianluigi; Wertheim, Carrie E.; Goldberg, Steven R. (2016-10-08). "Dopaminergic augmentation of delta-9-tetrahydrocannabinol (THC) discrimination: possible involvement of D2-induced formation of anandamide". Psychopharmacology 209 (2): 191–202. doi:10.1007/s00213-010-1789-8. ISSN 0033-3158. PMID 20179908.
- ↑ Zbukvic, Isabel C.; Ganella, Despina E.; Perry, Christina J.; Madsen, Heather B.; Bye, Christopher R.; Lawrence, Andrew J.; Kim, Jee Hyun (2016-06-01). "Role of Dopamine 2 Receptor in Impaired Drug-Cue Extinction in Adolescent Rats" (in en). Cerebral Cortex 26 (6): 2895–2904. doi:10.1093/cercor/bhw051. ISSN 1047-3211. PMID 26946126.
- ↑ 7.0 7.1 "Selective degeneration of dopaminergic neurons by MPP(+) and its rescue by D2 autoreceptors in Drosophila primary culture.". J Neurochem 126 (4): 529–40. 2013. doi:10.1111/jnc.12228. PMID 23452092.
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