Chemistry:Ciladopa

From HandWiki
Short description: Chemical compound
Ciladopa
Ciladopa Structure.svg
Clinical data
Routes of
administration
Oral
ATC code
  • none
Legal status
Legal status
  • In general: uncontrolled
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
Chemical and physical data
FormulaC21H26N2O4
Molar mass370.449 g·mol−1
3D model (JSmol)

Ciladopa (AY-27,110) is a dopamine agonist with a similar chemical structure to dopamine.[1] It was under investigation as an antiparkinsonian agent but was discontinued due to concerns of tumorogenesis in rodents.[2][3][4][5]

References

  1. Voith K (1985). "The comparative long-term effects of ciladopa (AY-27,110), a chemically novel dopaminergic agonist, in 6-OHDA-lesioned and intact rats". Psychopharmacology 85 (4): 405–9. doi:10.1007/BF00429654. PMID 3927334. 
  2. "Evaluation of ciladopa hydrochloride as a potential anti-Parkinson drug". Neuropharmacology 25 (9): 973–9. September 1986. doi:10.1016/0028-3908(86)90190-5. PMID 3774130. 
  3. "A double-blind evaluation of ciladopa in Parkinson's disease". Movement Disorders 2 (3): 211–7. 1987. doi:10.1002/mds.870020308. PMID 3332914. 
  4. "Advanced Parkinson's disease: use of partial dopamine agonist, ciladopa". Neurology 37 (5): 863–5. May 1987. doi:10.1212/wnl.37.5.863. PMID 3574692. 
  5. Lang AE (August 1987). "Update on dopamine agonists in Parkinson's disease: "beyond bromocriptine"". The Canadian Journal of Neurological Sciences 14 (3 Suppl): 474–82. doi:10.1017/s031716710003794x. PMID 3315148.