Chemistry:PF-592,379
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Short description: Dopamine receptor agonist compound
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| Routes of administration | Oral |
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| Formula | C13H21N3O |
| Molar mass | 235.331 g·mol−1 |
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PF-592,379 is a drug developed by Pfizer which acts as a potent, selective and orally active agonist for the dopamine D3 receptor, which is under development as a potential medication for the treatment of female sexual dysfunction and male erectile dysfunction. Unlike some other less selective D3 agonists, a research study showed that PF-592,379 has little abuse potential in animal studies, and so was selected for further development and potentially human clinical trials.[1][2] Development has since been discontinued.[3]
See also
References
- ↑ "Pharmacokinetics and elucidation of the rates and routes of N-glucuronidation of PF-592379, an oral dopamine 3 agonist in rat, dog, and human". Xenobiotica; the Fate of Foreign Compounds in Biological Systems 40 (11): 730–42. November 2010. doi:10.3109/00498254.2010.514961. PMID 20836725.
- ↑ "Lack of abuse potential in a highly selective dopamine D3 agonist, PF-592,379, in drug self-administration and drug discrimination in rats". Behavioural Pharmacology 23 (3): 280–91. June 2012. doi:10.1097/FBP.0b013e3283536d21. PMID 22470105.
- ↑ "Drug Profile: PF 592379". Adis Insight. Springer Nature Switzerland AG. http://adisinsight.springer.com/drugs/800025529.
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