Chemistry:L-741,626
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Short description: Chemical compound
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| Formula | C20H21ClN2O |
| Molar mass | 340.85 g·mol−1 |
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L-741,626 is a drug which acts as a potent and selective antagonist for the dopamine receptor D2. It has good selectivity over the related D3 and D4 subtypes and other receptors. L-741,626 is used for laboratory research into brain function and has proved particularly useful for distinguishing D2 mediated responses from those produced by the closely related D3 subtype, and for studying the roles of these subtypes in the action of cocaine and amphetamines in the brain.[1][2][3][4][5][6][7][8][9][10]
References
- ↑ "Antagonism of the effects of (+)-PD 128907 on midbrain dopamine neurones in rat brain slices by a selective D2 receptor antagonist L-741,626". British Journal of Pharmacology 119 (7): 1491–7. December 1996. doi:10.1111/j.1476-5381.1996.tb16063.x. PMID 8968560.
- ↑ "Psychomotor-activating effects mediated by dopamine D(2) and D(3) receptors in the nucleus accumbens". Pharmacology Biochemistry and Behavior 67 (1): 161–8. September 2000. doi:10.1016/S0091-3057(00)00311-7. PMID 11113496.
- ↑ "Antagonism of the discriminative stimulus effects of cocaine at two training doses by dopamine D2-like receptor antagonists". Psychopharmacology 158 (2): 146–53. November 2001. doi:10.1007/s002130100872. PMID 11702088.
- ↑ "Evidence for regulation of body temperature in rats by dopamine D2 receptor and possible influence of D1 but not D3 and D4 receptors". Neuropharmacology 44 (8): 1047–53. June 2003. doi:10.1016/S0028-3908(03)00113-8. PMID 12763098.
- ↑ "Analogues of the dopamine D2 receptor antagonist L741,626: Binding, function, and SAR". Bioorganic & Medicinal Chemistry Letters 17 (3): 745–9. February 2007. doi:10.1016/j.bmcl.2006.10.076. PMID 17095222.
- ↑ "The discriminative stimulus effects of dopamine D2- and D3-preferring agonists in rats". Psychopharmacology 203 (2): 317–27. April 2009. doi:10.1007/s00213-008-1323-4. PMID 18807248.
- ↑ "Penile erection and yawning induced by dopamine D2-like receptor agonists in rats: influence of strain and contribution of dopamine D2, but not D3 and D4 receptors". Behavioural Pharmacology 20 (4): 303–11. July 2009. doi:10.1097/FBP.0b013e32832ec5aa. PMID 19584712.
- ↑ "D2 dopamine receptor subtype-mediated hyperactivity and amphetamine responses in a model of ADHD". Neurobiology of Disease 37 (1): 228–36. January 2010. doi:10.1016/j.nbd.2009.10.009. PMID 19840852.
- ↑ "Dopamine D3 and D2 receptor mechanisms in the abuse-related behavioral effects of cocaine: studies with preferential antagonists in squirrel monkeys". The Journal of Pharmacology and Experimental Therapeutics 334 (2): 556–65. August 2010. doi:10.1124/jpet.110.167619. PMID 20494958.
- ↑ "Blockade of dopamine D3 but not D2 receptors reverses the novel object discrimination impairment produced by post-weaning social isolation: implications for schizophrenia and its treatment". The International Journal of Neuropsychopharmacology 15 (4): 471–484. March 2011. doi:10.1017/S1461145711000435. PMID 21414250.
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