Chemistry:SKF-38,393
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Short description: Chemical compound
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| Formula | C16H17NO2 |
| Molar mass | 255.317 g·mol−1 |
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SKF-38,393 is a synthetic compound of the benzazepine chemical class which acts as a selective D1/D5 receptor partial agonist.[1] It has stimulant and anorectic effects.[2][3]
The trimethylation of SKF-38,393 leads to a named agent called Trepipam.
As with fenoldopam the inclusion of a chlorine halogen gave an agent that is called SKF-81,297.
References
- ↑ "Autoradiographic distribution of the D1 agonist [3H]SKF 38393, in the rat brain and spinal cord. Comparison with the distribution of D2 dopamine receptors". Neuroscience 19 (1): 125–37. September 1986. doi:10.1016/0306-4522(86)90010-2. PMID 2946980.
- ↑ "The dopamine D1 receptor agonists, A68930 and SKF 38393, induce arousal and suppress REM sleep in the rat". European Journal of Pharmacology 235 (1): 83–7. April 1993. doi:10.1016/0014-2999(93)90823-Z. PMID 8100197.
- ↑ "The anorectic effect of SK&F 38393, a selective dopamine D1 receptor agonist: a microstructural analysis of feeding and related behaviour". Psychopharmacology 100 (2): 182–7. 1990. doi:10.1007/BF02244403. PMID 1968277.
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