Chemistry:L-745,870
From HandWiki
Short description: Chemical compound
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| Formula | C18H19ClN4 |
| Molar mass | 326.83 g·mol−1 |
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L-745,870 is a drug which acts as a dopamine receptor antagonist selective for the D4 subtype, and has antipsychotic effects in animal models, though it was not effective in human trials.[1][2][3]
References
- ↑ "Schizophrenia and L-745,870, a novel dopamine D4 receptor antagonist". Trends in Pharmacological Sciences 18 (6): 186–8. June 1997. doi:10.1016/s0165-6147(97)01066-3. PMID 9226994.
- ↑ "Regulation of working memory by dopamine D4 receptor in rats". Neuropsychopharmacology 29 (9): 1648–55. September 2004. doi:10.1038/sj.npp.1300491. PMID 15138447.
- ↑ "Effects of dopamine D4 receptor antagonist on spontaneous alternation in rats". Behavioral and Brain Functions 4: 49. 2008. doi:10.1186/1744-9081-4-49. PMID 18945334.
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