Chemistry:ABT-724
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Short description: Chemical compound
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| Formula | C17H19N5 |
| Molar mass | 293.374 g·mol−1 |
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ABT-724 is a drug which acts as a dopamine agonist, and is selective for the D4 subtype.[1] It was developed as a possible drug for the treatment of erectile dysfunction,[2] although poor oral bioavailability means alternative drugs such as ABT-670 may be more likely to be developed commercially.[3] Nonetheless, it continues to be used in scientific research into the function of the D4 receptor.[4][5]
See also
- ABT-670
- Bremelanotide
- Cabergoline
- Flibanserin
- Intrinsa
- Melanotan II
- Pramipexole
- PF-219,061
- Tibolone
- UK-414,495
References
- ↑ "Activation of dopamine D4 receptors by ABT-724 induces penile erection in rats". Proceedings of the National Academy of Sciences of the United States of America 101 (17): 6758–6763. April 2004. doi:10.1073/pnas.0308292101. PMID 15087502. Bibcode: 2004PNAS..101.6758B.
- ↑ "Discovery of 2-(4-pyridin-2-ylpiperazin-1-ylmethyl)-1H-benzimidazole (ABT-724), a dopaminergic agent with a novel mode of action for the potential treatment of erectile dysfunction". Journal of Medicinal Chemistry 47 (15): 3853–3864. July 2004. doi:10.1021/jm030505a. PMID 15239663.
- ↑ "Discovery of 3-methyl-N-(1-oxy-3',4',5',6'-tetrahydro-2'H-[2,4'-bipyridine]-1'-ylmethyl)benzamide (ABT-670), an orally bioavailable dopamine D4 agonist for the treatment of erectile dysfunction". Journal of Medicinal Chemistry 49 (25): 7450–7465. December 2006. doi:10.1021/jm060662k. PMID 17149874.
- ↑ "Agonist and antagonist properties of antipsychotics at human dopamine D4.4 receptors: G-protein activation and K+ channel modulation in transfected cells". The International Journal of Neuropsychopharmacology 11 (3): 293–307. May 2008. doi:10.1017/S1461145707008061. PMID 17897483.
- ↑ "Dopamine D4 receptor involvement in the discriminative stimulus effects in rats of LSD, but not the phenethylamine hallucinogen DOI". Psychopharmacology 203 (2): 265–277. April 2009. doi:10.1007/s00213-008-1238-0. PMID 18604600.
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