Chemistry:Stepholidine
From HandWiki
-Stepholidine.svg)
| |
| Names | |
|---|---|
| IUPAC name
3,9-Dimethoxyberbine-2,10-diol
| |
| Systematic IUPAC name
(13aS)-3,9-Dimethoxy-5,8,13,13a-tetrahydro-6H-isoquinolino[3,2-a]isoquinoline-2,10-diol | |
| Other names
l-Stepholidine
| |
| Identifiers | |
3D model (JSmol)
|
|
| ChEMBL | |
| ChemSpider | |
| MeSH | Stepholidine |
PubChem CID
|
|
| UNII | |
| |
| |
| Properties | |
| C19H21NO4 | |
| Molar mass | 327.374 g/mol |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
 verify (what is   ?)
| |
| Infobox references | |
(−)-Stepholidine is a protoberberine alkaloid found in the plant Stephania intermedia.
Stepholidine activity includes dual D2 receptor antagonist and D1 receptor agonist, and has shown antipsychotic activity in animal studies.[1][2][3][4]
See also
References
- ↑ "The antipsychotic potential of l-stepholidine-a naturally occurring dopamine receptor D(1) agonist and D (2) antagonist". Psychopharmacology 199 (2): 275–89. August 2008. doi:10.1007/s00213-008-1172-1. PMID 18521575.
- ↑ "Recent developments in studies of l-stepholidine and its analogs: chemistry, pharmacology and clinical implications". Curr. Med. Chem. 14 (28): 2996–3002. 2007. doi:10.2174/092986707782794050. PMID 18220736. http://www.bentham-direct.org/pages/content.php?CMC/2007/00000014/00000028/0007C.SGM.
- ↑ "(-)-Stepholidine: a potential novel antipsychotic drug with dual D1 receptor agonist and D2 receptor antagonist actions". Trends Pharmacol. Sci. 23 (1): 4–7. January 2002. doi:10.1016/S0165-6147(00)01929-5. PMID 11804640.
- ↑ "Dopamine D1 receptor agonist and D2 receptor antagonist effects of the natural product (-)-stepholidine: molecular modeling and dynamics simulations". Biophys. J. 93 (5): 1431–41. September 2007. doi:10.1529/biophysj.106.088500. PMID 17468175.
 |  |
