Chemistry:PD-168,077
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Short description: Chemical compound
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| Formula | C20H22N4O |
| Molar mass | 334.423 g·mol−1 |
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PD-168,077 is a drug which acts as a dopamine agonist selective for the D4 subtype,[1][2] which is used for researching the role of D4 receptors in the brain,[3][4][5] particularly relating to learning and memory.[6] The propensity to induce penile erections in rats means it could be used for this also?[7]
References
- ↑ "Topographically based search for an "Ethogram" among a series of novel D(4) dopamine receptor agonists and antagonists". Neuropsychopharmacology 22 (5): 538–544. May 2000. doi:10.1016/S0893-133X(99)00141-4. PMID 10731629.
- ↑ "Synthesis and functional activity of (2-aryl-1-piperazinyl)-N-(3-methylphenyl)acetamides: selective dopamine D4 receptor agonists". Bioorganic & Medicinal Chemistry 12 (13): 3471–3483. July 2004. doi:10.1016/j.bmc.2004.04.035. PMID 15186832.
- ↑ "Regulation of NMDA receptors by dopamine D4 signaling in prefrontal cortex". The Journal of Neuroscience 23 (30): 9852–9861. October 2003. doi:10.1523/JNEUROSCI.23-30-09852.2003. PMID 14586014.
- ↑ "PIP3EA and PD-168077, two selective dopamine D4 receptor agonists, induce penile erection in male rats: site and mechanism of action in the brain". The European Journal of Neuroscience 24 (7): 2021–2030. October 2006. doi:10.1111/j.1460-9568.2006.05043.x. PMID 17067298.
- ↑ "Stimulation of dopamine receptors in the paraventricular nucleus of the hypothalamus of male rats induces penile erection and increases extra-cellular dopamine in the nucleus accumbens: Involvement of central oxytocin". Neuropharmacology 52 (3): 1034–1043. March 2007. doi:10.1016/j.neuropharm.2006.10.019. PMID 17164075.
- ↑ "Facilitatory effect of the dopamine D4 receptor agonist PD168,077 on memory consolidation of an inhibitory avoidance learned response in C57BL/6J mice". Behavioural Brain Research 142 (1–2): 41–52. June 2003. doi:10.1016/S0166-4328(02)00371-6. PMID 12798264.
- ↑ "PIP3EA and PD-168077, two selective dopamine D4 receptor agonists, induce penile erection in male rats: site and mechanism of action in the brain". The European Journal of Neuroscience 24 (7): 2021–2030. October 2006. doi:10.1111/j.1460-9568.2006.05043.x. PMID 17067298.
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