Chemistry:Doxanthrine
From HandWiki
Short description: Chemical compound
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| Formula | C16H15NO3 |
| Molar mass | 269.300 g·mol−1 |
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Doxanthrine is a synthetic compound which is a potent and selective full agonist for the dopamine D1 receptor.[1][2] Doxanthrine has been shown to be orally active in producing contralateral rotation in the 6-hydroxydopamine rat model of Parkinson's disease.[3]
References
- ↑ "trans-2,3-dihydroxy-6a,7,8,12b-tetrahydro-6H-chromeno[3,4-c]isoquinoline: synthesis, resolution, and preliminary pharmacological characterization of a new dopamine D1 receptor full agonist". Journal of Medicinal Chemistry 49 (23): 6848–57. November 2006. doi:10.1021/jm0604979. PMID 17154515.
- ↑ "Comparison of the enantiomers of (±)-doxanthrine, a high efficacy full dopamine D1 receptor agonist, and a reversal of enantioselectivity at D1 versus alpha2C adrenergic receptors". European Neuropsychopharmacology 19 (2): 138–46. February 2009. doi:10.1016/j.euroneuro.2008.10.002. PMID 19028082.
- ↑ "Comparison of the D1 dopamine full agonists, dihydrexidine and doxanthrine, in the 6-OHDA rat model of Parkinson's disease". Psychopharmacology 222 (1): 81–87. July 2012. doi:10.1007/s00213-011-2625-5. PMID 22222862.
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