Chemistry:A-412997
From HandWiki
Short description: Chemical compound
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| Formula | C19H23N3O |
| Molar mass | 309.413 g·mol−1 |
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A-412,997 is a drug which acts as a dopamine agonist that is used in scientific research. It is the first drug developed that is a highly selective agonist for the D4 subtype, with significantly improved selectivity over older D4-preferring compounds such as PD-168,077 and CP-226,269.[1] In animal tests it improved cognitive performance in rats to a similar extent as methylphenidate, but without producing place preference or other signs of abuse liability.[2][3] Also unlike other dopamine agonists, selective D4 agonists do not cause side effects such as sedation and nausea, and so might have advantages over older dopamine agonist drugs.[4]
References
- ↑ "A-412997 is a selective dopamine D4 receptor agonist in rats". Pharmacology Biochemistry and Behavior 82 (1): 140–7. September 2005. doi:10.1016/j.pbb.2005.08.001. PMID 16153699.
- ↑ "A-412997, a selective dopamine D4 agonist, improves cognitive performance in rats". Pharmacology Biochemistry and Behavior 82 (1): 148–55. September 2005. doi:10.1016/j.pbb.2005.08.002. PMID 16154186.
- ↑ "Selective dopamine D4 receptor agonist (A-412997) improves cognitive performance and stimulates motor activity without influencing reward-related behaviour in rat". Behavioural Pharmacology 19 (8): 765–76. December 2008. doi:10.1097/FBP.0b013e32831c3b06. PMID 19020411.
- ↑ "Dopamine D2, but not D4, receptor agonists are emetogenic in ferrets". Pharmacology Biochemistry and Behavior 81 (1): 211–9. May 2005. doi:10.1016/j.pbb.2005.03.012. PMID 15894081.
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