Chemistry:CP-154,526
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| Preferred IUPAC name
N-Butyl-N-ethyl-2,5-dimethyl-7-(2,4,6-trimethylphenyl)-7H-pyrrolo[3,2-e]pyrimidin-4-amine | |
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3D model (JSmol)
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| Properties | |
| C23H32N4 | |
| Molar mass | 364.52698 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
 verify (what is   ?)
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Tracking categories (test):
CP-154,526 is a potent and selective antagonist of the corticotropin releasing hormone receptor 1 developed by Pfizer.[1]
CP-154,526 is under investigation for the potential treatment of alcoholism.[2][3]
See also
- Antalarmin
- Pexacerfont
- Corticotropin releasing hormone antagonist
References
- ↑ "CP-154,526: a potent and selective nonpeptide antagonist of corticotropin releasing factor receptors". Proceedings of the National Academy of Sciences of the United States of America 93 (19): 10477–82. September 1996. doi:10.1073/pnas.93.19.10477. PMID 8816826. Bibcode: 1996PNAS...9310477S.
- ↑ "Drug Has Potential To Prevent Alcoholics From Relapsing". Science News. ScienceDaily. 2008-08-02. https://www.sciencedaily.com/releases/2008/07/080730175518.htm.
- ↑ "Corticotropin-releasing factor-1 receptor involvement in behavioral neuroadaptation to ethanol: a urocortin1-independent mechanism". Proceedings of the National Academy of Sciences of the United States of America 105 (26): 9070–5. July 2008. doi:10.1073/pnas.0710181105. PMID 18591672. Bibcode: 2008PNAS..105.9070P.
Further reading
- "The pharmacology of CP-154,526, a non-peptide antagonist of the CRH1 receptor: a review". CNS Drug Reviews 9 (1): 57–96. 2006. doi:10.1111/j.1527-3458.2003.tb00244.x. PMID 12595912.
- "Effects of corticotropin-releasing factor receptor-1 antagonists on the brain stress system responses to morphine withdrawal". Molecular Pharmacology 77 (5): 864–73. May 2010. doi:10.1124/mol.109.062463. PMID 20159948.
- "Pretreatment with CP-154526 blocks the modifying effects of alarm pheromone on components of sexual behavior in male, but not in female, rats". Chemical Senses 36 (7): 623–32. September 2011. doi:10.1093/chemse/bjr017. PMID 21502338.
External links
- CP+154526 at the US National Library of Medicine Medical Subject Headings (MeSH)
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