Chemistry:Bepridil
 | |
| Clinical data | |
|---|---|
| Trade names | Vascor |
| AHFS/Drugs.com | Monograph |
| MedlinePlus | a699051 |
| Pregnancy category |
|
| Routes of administration | Oral |
| ATC code | |
| Pharmacokinetic data | |
| Bioavailability | Well absorbed |
| Protein binding | 99% |
| Metabolism | Hepatic, CYP3A4-mediated |
| Elimination half-life | 42 hours |
| Excretion | Renal |
| Identifiers | |
| |
| CAS Number | |
| PubChem CID | |
| IUPHAR/BPS | |
| DrugBank | |
| ChemSpider | |
| UNII | |
| ChEBI | |
| ChEMBL | |
| Chemical and physical data | |
| Formula | C24H34N2O |
| Molar mass | 366.549 g·mol−1 |
| 3D model (JSmol) | |
| |
| |
| (verify) | |
Bepridil (trade name Vascor) is an diamine calcium channel blocker once used to treat angina pectoris. It is no longer sold in the United States.
It is nonselective.[1]
It has been discussed as a possible option in the treatment of atrial fibrillation.[2]
It has been implicated in causing ventricular arrhythmia (torsades de pointes).
Ebola research
In June 2015 a research paper [3] was published finding bepridil to result in a 100% survival rate for mice exposed to ebola during an experiment searching for potential pharmaceutical ebola treatments; indicating its potential use in future ebola research and therapy.[4]
SARS-CoV-2 research
A research paper [5] showed that Bepridil inhibited cytopathogenic effects induced by SARS-CoV-2 in Vero E6 cells and in A549 cells in an in vitro assay.
References
- ↑ "Voltage-dependent blockade of diverse types of voltage-gated Ca2+ channels expressed in Xenopus oocytes by the Ca2+ channel antagonist mibefradil (Ro 40-5967)". Molecular Pharmacology 48 (3): 540–549. September 1995. PMID 7565636. http://molpharm.aspetjournals.org/cgi/pmidlookup?view=long&pmid=7565636.
- ↑ "Use of bepridil in combination with Ic antiarrhythmic agent in converting persistent atrial fibrillation to sinus rhythm". Circulation Journal 72 (5): 709–715. May 2008. doi:10.1253/circj.72.709. PMID 18441448.
- ↑ "A screen of approved drugs and molecular probes identifies therapeutics with anti-Ebola virus activity". Science Translational Medicine 7 (290): 290ra89. June 2015. doi:10.1126/scitranslmed.aaa5597. PMID 26041706.
- ↑ "Zoloft as Ebola cure? Antidepressant is one of a number of promising drugs being looked at by scientists.". Washington Post. 4 June 2015. https://www.washingtonpost.com/news/to-your-health/wp/2015/06/03/zoloft-as-ebola-cure-anti-depressant-is-one-of-a-number-of-promising-drugs-being-looked-at-by-scientists/.
- ↑ "Bepridil is potent against SARS-CoV-2 in vitro". Proceedings of the National Academy of Sciences of the United States of America 118 (10): e2012201118. March 2021. doi:10.1073/pnas.2012201118. PMID 33597253. Bibcode: 2021PNAS..11812201V.
External links
 |  |
