Chemistry:P-1075
From HandWiki
P-1075 is an ATP-sensitive potassium channel opener which was under development for the treatment of androgenic alopecia (pattern hair loss), arrhythmias, and ischemic heart disorders but was never marketed.[1][2][3][4][5] It has been found to stimulate cultured hair follicles and to promote hair growth in balding stump-tailed macaques.[3][4][5] The drug was being developed by AstraZeneca and LEO Pharma.[1][2] It reached phase 2 clinical trials for alopecia and the preclinical research stage of development for arrhythmia and ischemic heart disorders prior to the discontinuation of its development by 2000.[1][2] In terms of chemical structure, P-1075 is a guanidine derivative and a more potent analogue of pinacidil.[3]
See also
- List of investigational hair loss drugs
- ATP-sensitive potassium channel § Stimulation of hair growth
References
- ↑ 1.0 1.1 1.2 "P 1075". 3 November 2000. https://adisinsight.springer.com/drugs/800001364.
- ↑ 2.0 2.1 2.2 "Delving into the Latest Updates on P-1075 with Synapse". 20 July 2025. https://synapse.patsnap.com/drug/77fe7b6a18c74316a5d6140e82982b9c.
- ↑ 3.0 3.1 3.2 "Potassium channel conductance as a control mechanism in hair follicles". The Journal of Investigative Dermatology 101 (1 Suppl): 148S–152S. July 1993. doi:10.1111/1523-1747.ep12363290. PMID 8326149.
- ↑ 4.0 4.1 "Minoxidil: mechanisms of action on hair growth". The British Journal of Dermatology 150 (2): 186–194. February 2004. doi:10.1111/j.1365-2133.2004.05785.x. PMID 14996087.
- ↑ 5.0 5.1 "Minoxidil use in dermatology, side effects and recent patents". Recent Patents on Inflammation & Allergy Drug Discovery 6 (2): 130–136. May 2012. doi:10.2174/187221312800166859. PMID 22409453. "Other potassium channel openers, like diazoxide [39, 40] and pinacidil [41] can cause hypertrichosis in humans as well as minoxidil. In balding macaques minoxidil, cromakalin and P-1075 (a pinacidil analogue) stimulate hair growth in about 20 weeks of topical treatment, whereas a fourth potassium channel opener, called RP49356, is not effective [42]. Harmon et al. suggested that minoxidil, diazoxide, cromakalin and pinacidil increased uptake of thymidine in hair growth cultures of mouse vibrissae follicles [43].".
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