Chemistry:Saredutant

Saredutant
Clinical data
ATC code	none;
Identifiers
	IUPAC name N-[(2S)-4-(4-acetamido-4-phenylpiperidin-1-yl)- 2-(3,4-dichlorophenyl)butyl]-N-methylbenzamide;
CAS Number	142001-63-6 ;
PubChem CID	104974;
IUPHAR/BPS	2111;
ChemSpider	94726 ;
UNII	720U2QK8I5;
ChEMBL	ChEMBL308148 ;
Chemical and physical data
Formula	C31H35Cl2N3O2
Molar mass	552.54 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES Clc1ccc(cc1Cl)[C@H](CCN3CCC(c2ccccc2)(NC(=O)C)CC3)CN(C(=O)c4ccccc4)C;
	InChI InChI=1S/C31H35Cl2N3O2/c1-23(37)34-31(27-11-7-4-8-12-27)16-19-36(20-17-31)18-15-26(25-13-14-28(32)29(33)21-25)22-35(2)30(38)24-9-5-3-6-10-24/h3-14,21,26H,15-20,22H2,1-2H3,(H,34,37)/t26-/m1/s1 ; Key:PGKXDIMONUAMFR-AREMUKBSSA-N ;
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Short description: Chemical compound

Saredutant (SR-48,968) is a drug that acts as a NK₂ receptor antagonist.^[1] It was under development by Sanofi-Aventis as a novel antidepressant and anxiolytic and made it to phase III clinical trials. However, in May 2009, Sanofi-Aventis published its quarterly results and announced the cessation of 14 research/development projects, among which was saredutant for the treatment of major depressive disorder.^[2]

References

↑ "ACS chemical neuroscience molecule spotlight on Saredutant". ACS Chemical Neuroscience 1 (10): 653–4. October 2010. doi:10.1021/cn100061r. PMID 22776916.
↑ "Letter to the stockholders of Sanofi-Aventis". May 2009. http://www.sanofi-aventis.com/binaries/Lettre18_FR_Web_acc_tcm29-25341.pdf.

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Original source: https://en.wikipedia.org/wiki/Saredutant. Read more

[pmid22776916-1] "ACS chemical neuroscience molecule spotlight on Saredutant". ACS Chemical Neuroscience 1 (10): 653–4. October 2010. doi:10.1021/cn100061r. PMID 22776916.

[2] "Letter to the stockholders of Sanofi-Aventis". May 2009. http://www.sanofi-aventis.com/binaries/Lettre18_FR_Web_acc_tcm29-25341.pdf.

[1]

[2]

v t e Anxiolytics (N05B)
5-HT_1AR agonists	Buspirone Gepirone^† Tandospirone
GABA_AR PAMs	Benzodiazepines: Adinazolam Alprazolam Bromazepam Camazepam Chlordiazepoxide Clobazam Clonazepam Clorazepate Clotiazepam Cloxazolam Diazepam^# Ethyl loflazepate Etizolam Fludiazepam Halazepam Ketazolam Lorazepam^# Medazepam Nordazepam Oxazepam Pinazepam Prazepam; Others: Alpidem^‡ Barbiturates (e.g., phenobarbital) Carbamates (e.g., meprobamate) Chlormezanone^‡ Ethanol (alcohol) Etifoxine Imepitoin; Herbs: Kava Skullcap Valerian
Gabapentinoids (α₂δ VDCC blockers)	Gabapentin Gabapentin enacarbil Phenibut Pregabalin
Antidepressants	SSRIs (e.g., escitalopram) SNRIs (e.g., duloxetine) SARIs (e.g., trazodone) TCAs (e.g., clomipramine^#) TeCAs (e.g., mirtazapine) MAOIs (e.g., phenelzine); Others: Agomelatine Bupropion Tianeptine Vilazodone Vortioxetine
Sympatholytics (Antiadrenergics)	Alpha-1 blockers (e.g., prazosin) Alpha-2 agonists (e.g., clonidine, dexmedetomidine, guanfacine) Beta blockers (e.g., propranolol)
Others	Benzoctamine Cannabidiol Cycloserine Fabomotizole Hydroxyzine Kanna Lavender Lorpiprazole Mebicar Mepiprazole Nicotine Opipramol Oxaflozane^‡ Phenaglycodol Phenibut Picamilon Selank Tiagabine Tofisopam Validolum
^#WHO-EM ^‡Withdrawn from market Clinical trials: ^†Phase III ^§Never to phase III

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Clinical data

ATC code	none
Identifiers
IUPAC name N-[(2S)-4-(4-acetamido-4-phenylpiperidin-1-yl)- 2-(3,4-dichlorophenyl)butyl]-N-methylbenzamide
CAS Number	142001-63-6^N
PubChem CID	104974
IUPHAR/BPS	2111
ChemSpider	94726^Y
UNII	720U2QK8I5
ChEMBL	ChEMBL308148^Y
Chemical and physical data
Formula	C₃₁H₃₅Cl₂N₃O₂
Molar mass	552.54 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES Clc1ccc(cc1Cl)[C@H](CCN3CCC(c2ccccc2)(NC(=O)C)CC3)CN(C(=O)c4ccccc4)C
InChI InChI=1S/C31H35Cl2N3O2/c1-23(37)34-31(27-11-7-4-8-12-27)16-19-36(20-17-31)18-15-26(25-13-14-28(32)29(33)21-25)22-35(2)30(38)24-9-5-3-6-10-24/h3-14,21,26H,15-20,22H2,1-2H3,(H,34,37)/t26-/m1/s1^Y Key:PGKXDIMONUAMFR-AREMUKBSSA-N^Y
^NY (what is this?) (verify)

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