Chemistry:7-OH-DPAT
From HandWiki
Short description: Dopamine receptor agonist compound
| |
| Names | |
|---|---|
| IUPAC name
7-Hydroxy-N,N-dipropyl-2-aminotetralin[citation needed]
| |
| Systematic IUPAC name
7-(Dipropylamino)-5,6,7,8-tetrahydronaphthalen-2-ol[1] | |
| Identifiers | |
3D model (JSmol)
|
|
| Abbreviations | 7-OH-DPAT |
| ChEMBL | |
| ChemSpider | |
| MeSH | 7-Hydroxy-2-N,N-dipropylaminotetralin |
PubChem CID
|
|
| UNII | |
| |
| |
| Properties | |
| C16H25NO | |
| Molar mass | 247.382 g·mol−1 |
| log P | 3.653 |
| Acidity (pKa) | 10.389 |
| Basicity (pKb) | 3.608 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
 verify (what is   ?)
| |
| Infobox references | |
Tracking categories (test):
7-OH-DPAT is a synthetic compound that acts as a dopamine receptor agonist with reasonable selectivity for the D3 receptor subtype,[2][3][4] and low affinity for serotonin receptors, unlike its structural isomer 8-OH-DPAT.[5][6][7] 7-OH-DPAT is self-administered in several animal models, and is used to study its addiction effects to cocaine.[8][9][10][11][12]
See also
References
- ↑ "7-hydroxy-2-N,N-dipropylaminotetralin - PubChem Public Chemical Database". The PubChem Project. USA: National Center for Biotechnology Information. https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=1219.
- ↑ "Further in vitro and in vivo studies with the putative presynaptic dopamine agonist N,N-dipropyl-7-hydroxy-2-aminotetralin". Naunyn-Schmiedeberg's Archives of Pharmacology 336 (5): 494–501. November 1987. doi:10.1007/bf00169305. PMID 2830544.
- ↑ "Identification, characterization, and localization of the dopamine D3 receptor in rat brain using 7-[3Hhydroxy-N,N-di-n-propyl-2-aminotetralin"]. Proceedings of the National Academy of Sciences of the United States of America 89 (17): 8155–9. September 1992. doi:10.1073/pnas.89.17.8155. PMID 1518841. Bibcode: 1992PNAS...89.8155L.
- ↑ Lévesque D (August 1996). "Aminotetralin drugs and D3 receptor functions. What may partially selective D3 receptor ligands tell us about dopamine D3 receptor functions?". Biochemical Pharmacology 52 (4): 511–8. doi:10.1016/0006-2952(96)00239-0. PMID 8759022.
- ↑ "(+)-cis-8-Hydroxy-1-methyl-2-(di-n-propylamino)tetralin: a potent and highly stereoselective 5-hydroxytryptamine receptor agonist". Journal of Medicinal Chemistry 30 (11): 2105–9. November 1987. doi:10.1021/jm00394a029. PMID 2959776.
- ↑ "Molecular basis for the binding of 2-aminotetralins to human dopamine D2A and D3 receptors". Molecular Pharmacology 46 (2): 299–312. August 1994. PMID 8078492.
- ↑ "Additive hypothermic effects of the 5-HT1A receptor agonist 8-OH-DPAT and the dopamine D2/3 receptor agonist 7-OH-DPAT in the rat". Acta Physiologica Scandinavica 172 (3): 205–9. July 2001. doi:10.1046/j.1365-201x.2001.00858.x. PMID 11472307.
- ↑ Acri, J. B.; Carter, S. R.; Alling, K.; Geter-Douglass, B.; Dijkstra, D.; Wikström, H.; Katz, J. L.; Witkin, J. M. (1995). "Assessment of cocaine-like discriminative stimulus effects of dopamine D3 receptor ligands". European Journal of Pharmacology 281 (2): R7–R9. doi:10.1016/0014-2999(95)00411-D. PMID 7589197.
- ↑ Lamas, X.; Negus, S. S.; Nader, M. A.; Mello, N. K. (1996). "Effects of the putative dopamine D3 receptor agonist 7-OH-DPAT in rhesus monkeys trained to discriminate cocaine from saline". Psychopharmacology 124 (4): 306–314. doi:10.1007/bf02247435. PMID 8739545.
- ↑ Nader, M. A.; Mach, R. H. (1996). "Self-administration of the dopamine D3 agonist 7-OH-DPAT in rhesus monkeys is modified by prior cocaine exposure". Psychopharmacology 125 (1): 13–22. doi:10.1007/bf02247388. PMID 8724444.
- ↑ Barrett, A. C.; Miller, J. R.; Dohrmann, J. M.; Caine, S. B. (2004). "Effects of dopamine indirect agonists and selective D1-like and D2-like agonists and antagonists on cocaine self-administration and food maintained responding in rats". Neuropharmacology 47: 256–273. doi:10.1016/j.neuropharm.2004.07.007. PMID 15464142.
- ↑ Collins, G. T.; Butler, P.; Wayman, C.; Ratcliffe, S.; Gupta, P.; Oberhofer, G.; Caine, S. B. (2012). "Lack of abuse potential in a highly selective dopamine D3 agonist, PF-592,379, in drug self-administration and drug discrimination in rats". Behavioural Pharmacology 23 (3): 280–291. doi:10.1097/FBP.0b013e3283536d21. PMID 22470105.
 |  |
