Chemistry:Quinagolide
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Short description: Chemical compound
-Quinagolid_Structural_Formula_V1.svg) Structure without stereochemistry | |
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| Trade names | Norprolac |
| AHFS/Drugs.com | International Drug Names |
| Routes of administration | Oral |
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| Chemical and physical data | |
| Formula | C20H33N3O3S |
| Molar mass | 395.56 g·mol−1 |
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Quinagolide (INN, BAN), sold under the brand name Norprolac, is a selective dopamine D2 receptor agonist which is used to reduce elevated levels of prolactin (hyperprolactinemia).[1] It has also been found to be effective in the treatment of breast pain.[2] It is used in the UK, but it is not available in US.
Chemistry
Quinagolide is a racemate composed of the following two enantiomers:[3]
| Enantiomeres of Quinagolide | |
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-Quinagolid_Structural_Formula_V1.svg) (+)-Quinagolid CAS number: 140630-79-1 |
-Quinagolid_Structural_Formula_V1.svg) (-)-Quinagolid CAS number: 140630-80-4 |
References
- ↑ "The effect of quinagolide and cabergoline, two selective dopamine receptor type 2 agonists, in the treatment of prolactinomas". Clinical Endocrinology 53 (1): 53–60. July 2000. doi:10.1046/j.1365-2265.2000.01016.x. PMID 10931080.
- ↑ Pluchinotta, Alfonso M (20 April 2015). The Outpatient Breast Clinic: Aiming at Best Practice. Springer. pp. 167–. ISBN 978-3-319-15907-2. https://books.google.com/books?id=m5twCAAAQBAJ&pg=PA167.
- ↑ Rote Liste Service GmbH (Hrsg.) (2017) (in German). Rote Liste 2017 - Arzneimittelverzeichnis für Deutschland (einschließlich EU-Zulassungen und bestimmter Medizinprodukte) (57th ed.). Frankfurt/Main: Rote Liste Service GmbH. p. 214. ISBN 978-3-946057-10-9.
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