Biology:Cyclic nucleotide-gated channel alpha 1
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Short description: Protein-coding gene in the species Homo sapiens
Generic protein structure example |
Cyclic nucleotide-gated channel alpha 1, also known as CNGA1, is a human gene encoding an ion channel protein.[1] Heterologously expressed CNGA1 can form a functional channel that is permeable to calcium.[2] In rod photoreceptors, however, CNGA1 forms a heterotetramer with CNGB1 in a 3:1 ratio.[3][4][5] The addition of the CNGB1 channel imparts altered properties including more rapid channel kinetics and greater cAMP-activated current.[6] When light hits rod photoreceptors, cGMP concentrations decrease causing rapid closure of CNGA1/B1 channels and, therefore, hyperpolarization of the membrane potential.
See also
- Cyclic nucleotide-gated ion channel
References
- ↑ "Entrez Gene: CNGA1 cyclic nucleotide gated channel alpha 1". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1259.
- ↑ Kaupp, U. Benjamin; Niidome, Tetsuhiro; Tanabe, Tsutomu; Terada, Shoichi; Bönigk, Wolfgang; Stühmer, Walter; Cook, Neil J.; Kangawa, Kenji et al. (December 1989). "Primary structure and functional expression from complementary DNA of the rod photoreceptor cyclic GMP-gated channel". Nature 342 (6251): 762–766. doi:10.1038/342762a0. ISSN 0028-0836. PMID 2481236. Bibcode: 1989Natur.342..762K.
- ↑ Zheng, Jie; Trudeau, Matthew C.; Zagotta, William N. (December 2002). "Rod Cyclic Nucleotide-Gated Channels Have a Stoichiometry of Three CNGA1 Subunits and One CNGB1 Subunit". Neuron 36 (5): 891–896. doi:10.1016/s0896-6273(02)01099-1. ISSN 0896-6273. PMID 12467592.
- ↑ Zhong, Haining; Molday, Laurie L.; Molday, Robert S.; Yau, King-Wai (November 2002). "The heteromeric cyclic nucleotide-gated channel adopts a 3A:1B stoichiometry". Nature 420 (6912): 193–198. doi:10.1038/nature01201. ISSN 0028-0836. PMID 12432397. Bibcode: 2002Natur.420..193Z.
- ↑ Weitz, Dietmar; Ficek, Nicole; Kremmer, Elisabeth; Bauer, Paul J.; Kaupp, U.Benjamin (December 2002). "Subunit Stoichiometry of the CNG Channel of Rod Photoreceptors". Neuron 36 (5): 881–889. doi:10.1016/s0896-6273(02)01098-x. ISSN 0896-6273. PMID 12467591.
- ↑ Chen, T.-Y.; Peng, Y.-W.; Dhallan, R. S.; Ahamed, B.; Reed, R. R.; Yau, K.-W. (April 1993). "A new subunit of the cyclic nucleotide-gated cation channel in retinal rods". Nature 362 (6422): 764–767. doi:10.1038/362764a0. ISSN 0028-0836. PMID 7682292. Bibcode: 1993Natur.362..764C.
Further reading
- "International Union of Pharmacology. LI. Nomenclature and structure-function relationships of cyclic nucleotide-regulated channels". Pharmacological Reviews 57 (4): 455–62. December 2005. doi:10.1124/pr.57.4.8. PMID 16382102.
- "Primary structure and chromosomal localization of human and mouse rod photoreceptor cGMP-gated cation channel". The Journal of Biological Chemistry 267 (9): 6257–62. March 1992. doi:10.1016/S0021-9258(18)42689-0. PMID 1372902.
- "Identification and characterization of a partial cDNA expressing interleukin-1-like activity in keratinocytes". Molecular Immunology 29 (3): 431–8. March 1992. doi:10.1016/0161-5890(92)90031-R. PMID 1372959.
- "Human rod photoreceptor cGMP-gated channel: amino acid sequence, gene structure, and functional expression". The Journal of Neuroscience 12 (8): 3248–56. August 1992. doi:10.1523/JNEUROSCI.12-08-03248.1992. PMID 1379636.
- "Mutations in the gene encoding the alpha subunit of the rod cGMP-gated channel in autosomal recessive retinitis pigmentosa". Proceedings of the National Academy of Sciences of the United States of America 92 (22): 10177–81. October 1995. doi:10.1073/pnas.92.22.10177. PMID 7479749. Bibcode: 1995PNAS...9210177D.
- "Expression of cyclic nucleotide-gated cation channels in non-sensory tissues and cells". Neuropharmacology 33 (11): 1275–82. November 1994. doi:10.1016/0028-3908(94)90027-2. PMID 7532814. https://epub.ub.uni-muenchen.de/3654/1/3654.pdf.
- "Human rod cGMP-gated cation channel gene maps to 4p12-->centromere by chromosomal in situ hybridization". Genomics 16 (1): 302–3. April 1993. doi:10.1006/geno.1993.1187. PMID 7683629.
- "Generation and analysis of 280,000 human expressed sequence tags". Genome Research 6 (9): 807–28. September 1996. doi:10.1101/gr.6.9.807. PMID 8889549.
- "Novel homozygous mutation in the alpha subunit of the rod cGMP gated channel (CNGA1) in two Spanish sibs affected with autosomal recessive retinitis pigmentosa". Journal of Medical Genetics 39 (10): 66e–66. October 2002. doi:10.1136/jmg.39.10.e66. PMID 12362048.
- "An endogenous RNA transcript antisense to CNG(alpha)1 cation channel mRNA". Molecular Biology of the Cell 13 (10): 3696–705. October 2002. doi:10.1091/mbc.E02-03-0127. PMID 12388767.
- "The heteromeric cyclic nucleotide-gated channel adopts a 3A:1B stoichiometry". Nature 420 (6912): 193–8. November 2002. doi:10.1038/nature01201. PMID 12432397. Bibcode: 2002Natur.420..193Z.
- "Rod cyclic nucleotide-gated channels have a stoichiometry of three CNGA1 subunits and one CNGB1 subunit". Neuron 36 (5): 891–6. December 2002. doi:10.1016/S0896-6273(02)01099-1. PMID 12467592.
- "Assembly of retinal rod or cone Na(+)/Ca(2+)-K(+) exchanger oligomers with cGMP-gated channel subunits as probed with heterologously expressed cDNAs". Biochemistry 42 (15): 4593–600. April 2003. doi:10.1021/bi027276z. PMID 12693957. http://juser.fz-juelich.de/record/30216/files/27726.pdf.
- "Autosomal recessive retinitis pigmentosa in a Pakistani family mapped to CNGA1 with identification of a novel mutation". Molecular Vision 10: 884–9. November 2004. PMID 15570217.
- "Stage- and cell-specific expression of soluble guanylyl cyclase alpha and beta subunits, cGMP-dependent protein kinase I alpha and beta, and cyclic nucleotide-gated channel subunit 1 in the rat testis". Journal of Andrology 26 (2): 258–63. 2005. doi:10.1002/j.1939-4640.2005.tb01093.x. PMID 15713832.
External links
- GeneReviews/NCBI/NIH/UW entry on Retinitis Pigmentosa Overview
- CNGA1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
Original source: https://en.wikipedia.org/wiki/Cyclic nucleotide-gated channel alpha 1.
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