Biology:Cyclic nucleotide-gated channel alpha 1

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An Error has occurred retrieving Wikidata item for infobox Cyclic nucleotide-gated channel alpha 1, also known as CNGA1, is a human gene encoding an ion channel protein.[1] Heterologously expressed CNGA1 can form a functional channel that is permeable to calcium.[2] In rod photoreceptors, however, CNGA1 forms a heterotetramer with CNGB1 in a 3:1 ratio.[3][4][5] The addition of the CNGB1 channel imparts altered properties including more rapid channel kinetics and greater cAMP-activated current.[6] When light hits rod photoreceptors, cGMP concentrations decrease causing rapid closure of CNGA1/B1 channels and, therefore, hyperpolarization of the membrane potential.

See also

  • Cyclic nucleotide-gated ion channel


  1. "Entrez Gene: CNGA1 cyclic nucleotide gated channel alpha 1". Retrieved 2016-08-02. 
  2. Kaupp, U. Benjamin; Niidome, Tetsuhiro; Tanabe, Tsutomu; Terada, Shoichi; Bönigk, Wolfgang; Stühmer, Walter; Cook, Neil J.; Kangawa, Kenji et al. (December 1989). "Primary structure and functional expression from complementary DNA of the rod photoreceptor cyclic GMP-gated channel". Nature 342 (6251): 762–766. doi:10.1038/342762a0. ISSN 0028-0836. PMID 2481236. Bibcode1989Natur.342..762K. 
  3. Zheng, Jie; Trudeau, Matthew C.; Zagotta, William N. (December 2002). "Rod Cyclic Nucleotide-Gated Channels Have a Stoichiometry of Three CNGA1 Subunits and One CNGB1 Subunit". Neuron 36 (5): 891–896. doi:10.1016/s0896-6273(02)01099-1. ISSN 0896-6273. PMID 12467592. 
  4. Zhong, Haining; Molday, Laurie L.; Molday, Robert S.; Yau, King-Wai (November 2002). "The heteromeric cyclic nucleotide-gated channel adopts a 3A:1B stoichiometry". Nature 420 (6912): 193–198. doi:10.1038/nature01201. ISSN 0028-0836. PMID 12432397. Bibcode2002Natur.420..193Z. 
  5. Weitz, Dietmar; Ficek, Nicole; Kremmer, Elisabeth; Bauer, Paul J.; Kaupp, U.Benjamin (December 2002). "Subunit Stoichiometry of the CNG Channel of Rod Photoreceptors". Neuron 36 (5): 881–889. doi:10.1016/s0896-6273(02)01098-x. ISSN 0896-6273. PMID 12467591. 
  6. Chen, T.-Y.; Peng, Y.-W.; Dhallan, R. S.; Ahamed, B.; Reed, R. R.; Yau, K.-W. (April 1993). "A new subunit of the cyclic nucleotide-gated cation channel in retinal rods". Nature 362 (6422): 764–767. doi:10.1038/362764a0. ISSN 0028-0836. PMID 7682292. Bibcode1993Natur.362..764C. 

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.