Biology:KCNJ9
 Generic protein structure example |
G protein-activated inward rectifier potassium channel 3 is a protein that in humans is encoded by the KCNJ9 gene.[1][2][3]
Function
Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins. It associates with another G-protein-activated potassium channel to form a heteromultimeric pore-forming complex.[3]
Interactions
KCNJ9 has been shown to interact with KCNJ6.[4][5]
See also
- G protein-coupled inwardly-rectifying potassium channel
- Inward-rectifier potassium ion channel
References
- ↑ "Assignment of human G-protein-coupled inward rectifier K+ channel homolog GIRK3 gene to chromosome 1q21-q23". Genomics 29 (3): 808–9. Oct 1995. doi:10.1006/geno.1995.9928. PMID 8575783.
- ↑ "International Union of Pharmacology. LIV. Nomenclature and molecular relationships of inwardly rectifying potassium channels". Pharmacological Reviews 57 (4): 509–26. Dec 2005. doi:10.1124/pr.57.4.11. PMID 16382105.
- ↑ 3.0 3.1 "Entrez Gene: KCNJ9 potassium inwardly-rectifying channel, subfamily J, member 9". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3765.
- ↑ "Functional and biochemical evidence for G-protein-gated inwardly rectifying K+ (GIRK) channels composed of GIRK2 and GIRK3". The Journal of Biological Chemistry 275 (46): 36211–6. Nov 2000. doi:10.1074/jbc.M007087200. PMID 10956667.
- ↑ "G protein-coupled receptors form stable complexes with inwardly rectifying potassium channels and adenylyl cyclase". The Journal of Biological Chemistry 277 (48): 46010–9. Nov 2002. doi:10.1074/jbc.M205035200. PMID 12297500.
Further reading
- "Functional expression and characterization of G-protein-gated inwardly rectifying K+ channels containing GIRK3". The Journal of Membrane Biology 169 (2): 123–9. May 1999. doi:10.1007/s002329900524. PMID 10341034.
- "Co-expression of human Kir3 subunits can yield channels with different functional properties". Cellular Signalling 11 (12): 871–83. Dec 1999. doi:10.1016/S0898-6568(99)00059-5. PMID 10659995.
- "Genomic structure and expression of human KCNJ9 (Kir3.3/GIRK3)". Biochemical and Biophysical Research Communications 274 (2): 302–9. Aug 2000. doi:10.1006/bbrc.2000.3136. PMID 10913335. https://zenodo.org/record/1229522.
- "Functional and biochemical evidence for G-protein-gated inwardly rectifying K+ (GIRK) channels composed of GIRK2 and GIRK3". The Journal of Biological Chemistry 275 (46): 36211–6. Nov 2000. doi:10.1074/jbc.M007087200. PMID 10956667.
- "G protein-coupled receptors form stable complexes with inwardly rectifying potassium channels and adenylyl cyclase". The Journal of Biological Chemistry 277 (48): 46010–9. Nov 2002. doi:10.1074/jbc.M205035200. PMID 12297500.
- "Expression of G-protein inwardly rectifying potassium channels (GIRKs) in lung cancer cell lines". BMC Cancer 5: 104. 2006. doi:10.1186/1471-2407-5-104. PMID 16109170.
External links
- KCNJ9+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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