Biology:CatSper2
 Generic protein structure example |
CatSper2, is a protein which in humans is encoded by the CATSPER2 gene.[1][2] CatSper2 is a member of the cation channels of sperm family of protein. The four proteins in this family together form a Ca2+-permeant ion channel specific essential for the correct function of sperm cells.[3]
Function
Calcium ions play a primary role in the regulation of sperm motility. This gene belongs to a family of putative cation channels that are specific to spermatozoa and localize to the flagellum. The protein family features a single repeat with six membrane-spanning segments and a predicted calcium-selective pore region. This gene is part of a tandem repeat on chromosome 15q15; the second copy of this gene is thought to be a pseudogene.[4]
See also
References
- ↑ "A voltage-gated ion channel expressed specifically in spermatozoa". Proc. Natl. Acad. Sci. U.S.A. 98 (22): 12527–31. October 2001. doi:10.1073/pnas.221454998. PMID 11675491. Bibcode: 2001PNAS...9812527Q.
- ↑ "International Union of Pharmacology. L. Nomenclature and structure-function relationships of CatSper and two-pore channels". Pharmacol. Rev. 57 (4): 451–4. December 2005. doi:10.1124/pr.57.4.7. PMID 16382101.
- ↑ *"CatSper and Two-Pore Channels: Introduction". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. http://www.iuphar-db.org/IC/FamilyIntroductionForward?familyId=13.
- ↑ "Entrez Gene: CatSper2". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=117155.
Further reading
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2002. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Association of Catsper1 or -2 with Ca(v)3.3 leads to suppression of T-type calcium channel activity.". J. Biol. Chem. 281 (31): 22332–41. 2006. doi:10.1074/jbc.M511288200. PMID 16740636.
- Garbers DL (2001). "Ion channels. Swimming with sperm.". Nature 413 (6856): 579, 581–2. doi:10.1038/35098164. PMID 11595929. Bibcode: 2001Natur.413..579G.
- "A voltage-gated ion channel expressed specifically in spermatozoa.". Proc. Natl. Acad. Sci. U.S.A. 98 (22): 12527–31. 2001. doi:10.1073/pnas.221454998. PMID 11675491. Bibcode: 2001PNAS...9812527Q.
- "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039.
- "International Union of Pharmacology. L. Nomenclature and structure-function relationships of CatSper and two-pore channels.". Pharmacol. Rev. 57 (4): 451–4. 2005. doi:10.1124/pr.57.4.7. PMID 16382101.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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