Biology:CLCA1
From HandWiki
 Generic protein structure example |
Chloride channel accessory 1 is a protein that in humans is encoded by the CLCA1 gene.[1][2]
This gene encodes a member of the calcium sensitive chloride conductance protein family. To date, all members of this gene family map to the same region on chromosome 1p31-p22 and share a high degree of homology in size, sequence, and predicted structure, but differ significantly in their tissue distributions. The encoded protein is expressed as a precursor protein that is processed into two cell-surface-associated subunits, although the site at which the precursor is cleaved has not been precisely determined. The encoded protein may be involved in mediating calcium-activated chloride conductance in the intestine.[2] Protein structure prediction methods suggest the N-terminal region of CLCA1 protein is a zinc metalloprotease.[3]
See also
References
- ↑ "Genomic cloning, molecular characterization, and functional analysis of human CLCA1, the first human member of the family of Ca2+-activated Cl− channel proteins". Genomics 54 (2): 200–14. Jan 1999. doi:10.1006/geno.1998.5562. PMID 9828122.
- ↑ 2.0 2.1 "Entrez Gene: CLCA1 chloride channel, calcium activated, family member 1". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1179.
- ↑ "Novel conserved hydrolase domain in the CLCA family of alleged calcium-activated chloride channels". Proteins 63 (3): 424–39. 2006. doi:10.1002/prot.20887. PMID 16470849.
Further reading
- "Anion transport in heart". Physiol. Rev. 80 (1): 31–81. 2000. doi:10.1152/physrev.2000.80.1.31. PMID 10617765.
- "Molecular characteristics and functional diversity of CLCA family members". Clin. Exp. Pharmacol. Physiol. 27 (11): 901–5. 2001. doi:10.1046/j.1440-1681.2000.03358.x. PMID 11071307.
- "Identification of three novel members of the calcium-dependent chloride channel (CaCC) family predominantly expressed in the digestive tract and trachea". FEBS Lett. 455 (3): 295–301. 1999. doi:10.1016/S0014-5793(99)00891-1. PMID 10437792.
- "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. 2000. doi:10.1073/pnas.97.7.3491. PMID 10737800. Bibcode: 2000PNAS...97.3491D.
- "HIV-1 gp120 and chemokines activate ion channels in primary macrophages through CCR5 and CXCR4 stimulation". Proc. Natl. Acad. Sci. U.S.A. 97 (9): 4832–7. 2000. doi:10.1073/pnas.090521697. PMID 10758170. Bibcode: 2000PNAS...97.4832L.
- "A calcium-activated chloride channel (HCLCA1) is strongly related to IL-9 expression and mucus production in bronchial epithelium of patients with asthma". J. Allergy Clin. Immunol. 109 (2): 246–50. 2002. doi:10.1067/mai.2002.121555. PMID 11842292.
- "The large conductance potassium channel beta-subunit can interact with and modulate the functional properties of a calcium-activated chloride channel, CLCA1". J. Biol. Chem. 277 (25): 22119–22. 2002. doi:10.1074/jbc.C200215200. PMID 11994272.
- "Focal adhesion kinase activated by beta(4) integrin ligation to mCLCA1 mediates early metastatic growth". J. Biol. Chem. 277 (37): 34391–400. 2002. doi:10.1074/jbc.M205307200. PMID 12110680.
- "pCLCA1 becomes a cAMP-dependent chloride conductance mediator in Caco-2 cells". Biochem. Biophys. Res. Commun. 298 (4): 531–6. 2002. doi:10.1016/S0006-291X(02)02498-1. PMID 12408984.
- "A calcium-activated chloride channel blocker inhibits goblet cell metaplasia and mucus overproduction". Novartis Found. Symp.. Novartis Foundation Symposia 248: 150–65; discussion 165–70, 277–82. 2003. doi:10.1002/0470860790.ch10. ISBN 9780470844786. PMID 12568493.
- "The interacting binding domains of the beta(4) integrin and calcium-activated chloride channels (CLCAs) in metastasis". J. Biol. Chem. 278 (49): 49406–16. 2004. doi:10.1074/jbc.M309086200. PMID 14512419.
- "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039.
- "CLCA1 gene polymorphisms in chronic obstructive pulmonary disease". J. Med. Genet. 41 (3): 27e–27. 2004. doi:10.1136/jmg.2003.012484. PMID 14985398.
- "Association of the hCLCA1 gene with childhood and adult asthma". Genes Immun. 5 (7): 540–7. 2005. doi:10.1038/sj.gene.6364124. PMID 15318163.
- "The CLCA gene locus as a modulator of the gastrointestinal basic defect in cystic fibrosis". Hum. Genet. 115 (6): 483–91. 2005. doi:10.1007/s00439-004-1190-y. PMID 15490240.
- "hCLCA1 and mCLCA3 are secreted non-integral membrane proteins and therefore are not ion channels". J. Biol. Chem. 280 (29): 27205–12. 2005. doi:10.1074/jbc.M504654200. PMID 15919655.
- "Cloning and expression of Ca2+-activated chloride channel from rat brain". Biochem. Biophys. Res. Commun. 334 (2): 569–76. 2005. doi:10.1016/j.bbrc.2005.06.122. PMID 16023076.
External links
- CLCA1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
- Human CLCA1 genome location and CLCA1 gene details page in the UCSC Genome Browser.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
 |
