Biology:CACNG4
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Voltage-dependent calcium channel gamma-4 subunit is a protein that in humans is encoded by the CACNG4 gene.[1][2]
L-type calcium channels are composed of five subunits. The protein encoded by this gene represents one of these subunits, gamma, and is one of several gamma subunit proteins. It is an integral membrane protein that is thought to stabilize the calcium channel in an inactive (closed) state. This gene is a member of the neuronal calcium channel gamma subunit gene subfamily of the PMP-22/EMP/MP20 family and is located in a cluster with two similar gamma subunit-encoding genes.[2]
See also
- Voltage-dependent calcium channel
References
- ↑ "Identification of Three Novel Ca2+ Channel γ Subunit Genes Reveals Molecular Diversification by Tandem and Chromosome Duplication". Genome Res 9 (12): 1204–13. Jan 2000. doi:10.1101/gr.9.12.1204. PMID 10613843.
- ↑ 2.0 2.1 "Entrez Gene: CACNG4 calcium channel, voltage-dependent, gamma subunit 4". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27092.
Further reading
- "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039.
- "Human neuronal stargazin-like proteins, γ2, γ3 and γ4; an investigation of their specific localization in human brain and their influence on CaV2.1 voltage-dependent calcium channels expressed in Xenopus oocytes". BMC Neuroscience 4: 23. 2004. doi:10.1186/1471-2202-4-23. PMID 14505496.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Calcium channel gamma subunits provide insights into the evolution of this gene family". Gene 280 (1–2): 37–48. 2002. doi:10.1016/S0378-1119(01)00738-7. PMID 11738816.
- "A cluster of three novel Ca2+ channel gamma subunit genes on chromosome 19q13.4: evolution and expression profile of the gamma subunit gene family". Genomics 71 (3): 339–50. 2001. doi:10.1006/geno.2000.6440. PMID 11170751.
- "Molecular characterization of the gene encoding the gamma subunit of the human skeletal muscle 1,4-dihydropyridine-sensitive Ca2+ channel (CACNLG), cDNA sequence, gene structure, and chromosomal location". J. Biol. Chem. 268 (13): 9275–9. 1993. doi:10.1016/S0021-9258(18)98346-8. PMID 8387489.
External links
- CACNG4+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
- Human CACNG4 genome location and CACNG4 gene details page in the UCSC Genome Browser.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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