Biology:Q-type calcium channel
From HandWiki
Short description: Family of transport proteins
| calcium channel, voltage-dependent, P/Q type, alpha 1A subunit | |
|---|---|
| Identifiers | |
| Symbol | CACNA1A |
| Alt. symbols | CACNL1A4, SCA6, MHP1, MHP |
| IUPHAR | 532 |
| NCBI gene | 773 |
| HGNC | 1388 |
| OMIM | 601011 |
| RefSeq | NM_000068 |
| UniProt | O00555 |
| Other data | |
| Locus | Chr. 19 p13 |
The Q-type calcium channel is a type of voltage-dependent calcium channel. Like the others of this class, the α1 subunit is the one that determines most of the channel's properties.
They are poorly understood, but like R-type calcium channels, they appear to be present in cerebellar granule cells. They have a high threshold of activation and relatively slow kinetics.
Mutations in the CACNA1A gene that encodes this protein are responsible for familial hemiplegic migraine type 1 (FHM1), episodic ataxia type 2 (EA2) and spinocerebellar ataxia type 6 (SCA6).[1]
References
- ↑ "The electrophysiological footprint of CACNA1A disorders". Journal of Neurology 268 (7): 2493–2505. July 2021. doi:10.1007/s00415-021-10415-x. PMID 33544220.
External links
- Q-Type+Calcium+Channel at the US National Library of Medicine Medical Subject Headings (MeSH)
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