Biology:TPCN1
 Generic protein structure example |
Two pore segment channel 1 (TPC1) is a human protein encoded by the TPCN1 gene.[1] The protein encoded by this gene is an ion channel. In contrast to other calcium and sodium channels which have four homologous domains, each containing 6 transmembrane segments (S1 to S6), TPCN1 only contains two domains (each containing segments S1 to S6).[2][3][4]
Structure
The structure of a TPC1 ortholog from Arabidopsis thaliana has been solved by two laboratories.[5][6] The structures were solved using X-ray crystallography and contained the fold of a voltage-gated ion channel and EF hands. Only a single voltage sensor domain appears to responsible for voltage sensing.
Filoviral Infections
Genetic knockout and pharmacological inhibition experiments demonstrate that Two-pore Channels, TPC1 and TPC2, are required for infection by Filoviruses Ebola and Marburg in mice.[7]
See also
References
- ↑ "Entrez Gene: two pore segment channel 1". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=53373.
- ↑ "Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain". DNA Research 6 (5): 329–36. October 1999. doi:10.1093/dnares/6.5.329. PMID 10574461.
- ↑ "Molecular cloning of a novel form (two-repeat) protein related to voltage-gated sodium and calcium channels". Biochemical and Biophysical Research Communications 270 (2): 370–6. April 2000. doi:10.1006/bbrc.2000.2435. PMID 10753632.
- ↑ "International Union of Pharmacology. L. Nomenclature and structure-function relationships of CatSper and two-pore channels". Pharmacological Reviews 57 (4): 451–4. December 2005. doi:10.1124/pr.57.4.7. PMID 16382101.
- ↑ "Structure of the voltage-gated two-pore channel TPC1 from Arabidopsis thaliana". Nature 531 (7593): 196–201. March 2016. doi:10.1038/nature16446. PMID 26689363. Bibcode: 2016Natur.531..196G.
- ↑ "Structure, inhibition and regulation of two-pore channel TPC1 from Arabidopsis thaliana". Nature 531 (7593): 258–62. March 2016. doi:10.1038/nature17194. PMID 26961658. Bibcode: 2016Natur.531..258K.
- ↑ "Ebola virus. Two-pore channels control Ebola virus host cell entry and are drug targets for disease treatment". Science 347 (6225): 995–8. February 2015. doi:10.1126/science.1258758. PMID 25722412.
Further reading
- "Molecular cloning of a novel form (two-repeat) protein related to voltage-gated sodium and calcium channels". Biochemical and Biophysical Research Communications 270 (2): 370–6. April 2000. doi:10.1006/bbrc.2000.2435. PMID 10753632.
- "Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain". DNA Research 6 (5): 329–36. October 1999. doi:10.1093/dnares/6.5.329. PMID 10574461.
- "International Union of Pharmacology. L. Nomenclature and structure-function relationships of CatSper and two-pore channels". Pharmacological Reviews 57 (4): 451–4. December 2005. doi:10.1124/pr.57.4.7. PMID 16382101.
- "NAADP mobilizes calcium from acidic organelles through two-pore channels". Nature 459 (7246): 596–600. May 2009. doi:10.1038/nature08030. PMID 19387438. Bibcode: 2009Natur.459..596C.
- "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Research 9 (3): 99–106. June 2002. doi:10.1093/dnares/9.3.99. PMID 12168954.
External links
- TPCN1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
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