Biology:KCNJ12
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Short description: Protein-coding gene in the species Homo sapiens
![]() Generic protein structure example |
ATP-sensitive inward rectifier potassium channel 12 is a lipid-gated ion channel that in humans is encoded by the KCNJ12 gene.[1][2][3][4][5]
Function
This gene encodes an inwardly rectifying K+ channel that may be blocked by divalent cations. This protein is thought to be one of multiple inwardly rectifying channels that contribute to the cardiac inward rectifier current (IK1). The gene is located within the Smith–Magenis syndrome region on chromosome 17.[5]
Interactions
KCNJ12 has been shown to interact with:
- APBA1,[6][7]
- CASK,[6][7]
- DLG1,[6][7][8]
- DLG2,[6]
- DLG3,[6]
- DLG4,[6][7]
- LIN7A[6][7]
- LIN7B,[6][7] and
- LIN7C.[6][7]
See also
References
- ↑ Hansen, SB (May 2015). "Lipid agonism: The PIP2 paradigm of ligand-gated ion channels.". Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1851 (5): 620–8. doi:10.1016/j.bbalip.2015.01.011. PMID 25633344.
- ↑ "Cloning and functional expression of an inwardly rectifying K+ channel from human atrium". Circulation Research 76 (3): 343–50. Mar 1995. doi:10.1161/01.res.76.3.343. PMID 7859381.
- ↑ "Identification of human Kir2.2 (KCNJ12) gene encoding functional inward rectifier potassium channel in both mammalian cells and Xenopus oocytes". FEBS Letters 531 (2): 250–4. Nov 2002. doi:10.1016/S0014-5793(02)03512-3. PMID 12417321.
- ↑ "International Union of Pharmacology. LIV. Nomenclature and molecular relationships of inwardly rectifying potassium channels". Pharmacological Reviews 57 (4): 509–26. Dec 2005. doi:10.1124/pr.57.4.11. PMID 16382105.
- ↑ 5.0 5.1 "Entrez Gene: KCNJ12 potassium inwardly-rectifying channel, subfamily J, member 12". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3768.
- ↑ 6.0 6.1 6.2 6.3 6.4 6.5 6.6 6.7 6.8 "Protein trafficking and anchoring complexes revealed by proteomic analysis of inward rectifier potassium channel (Kir2.x)-associated proteins". The Journal of Biological Chemistry 279 (21): 22331–46. May 2004. doi:10.1074/jbc.M400285200. PMID 15024025.
- ↑ 7.0 7.1 7.2 7.3 7.4 7.5 7.6 "A multiprotein trafficking complex composed of SAP97, CASK, Veli, and Mint1 is associated with inward rectifier Kir2 potassium channels". The Journal of Biological Chemistry 279 (18): 19051–63. Apr 2004. doi:10.1074/jbc.M400284200. PMID 14960569.
- ↑ "Inward rectifier potassium channel Kir2.2 is associated with synapse-associated protein SAP97". Journal of Cell Science 114 (Pt 5): 987–98. Mar 2001. doi:10.1242/jcs.114.5.987. PMID 11181181.
Further reading
- "Kir2.2v: a possible negative regulator of the inwardly rectifying K+ channel Kir2.2". FEBS Letters 386 (2–3): 211–4. May 1996. doi:10.1016/0014-5793(96)00445-0. PMID 8647284.
- "The human inward rectifying K+ channel Kir 2.2 (KCNJ12) gene: gene structure, assignment to chromosome 17p11.1, and identification of a simple tandem repeat polymorphism". Genomics 39 (1): 113–6. Jan 1997. doi:10.1006/geno.1996.4450. PMID 9027495.
- "An alternate promoter directs expression of a truncated, muscle-specific isoform of the human ankyrin 1 gene". The Journal of Biological Chemistry 273 (3): 1339–48. Jan 1998. doi:10.1074/jbc.273.3.1339. PMID 9430667.
- "The inwardly rectifying potassium channel subunit Kir2.2v (KCNJN1) maps to 17p11.2-->p11.1". Cytogenetics and Cell Genetics 79 (1–2): 85–7. 1998. doi:10.1159/000134688. PMID 9533018.
- "Inward rectifier potassium channel Kir2.2 is associated with synapse-associated protein SAP97". Journal of Cell Science 114 (Pt 5): 987–98. Mar 2001. doi:10.1242/jcs.114.5.987. PMID 11181181.
- "Heteromerization of Kir2.x potassium channels contributes to the phenotype of Andersen's syndrome". Proceedings of the National Academy of Sciences of the United States of America 99 (11): 7774–9. May 2002. doi:10.1073/pnas.102609499. PMID 12032359. Bibcode: 2002PNAS...99.7774P.
- "A glutamate residue at the C terminus regulates activity of inward rectifier K+ channels: implication for Andersen's syndrome". Proceedings of the National Academy of Sciences of the United States of America 99 (12): 8430–5. Jun 2002. doi:10.1073/pnas.122682899. PMID 12034888. Bibcode: 2002PNAS...99.8430C.
- "Plasticity of KIR channels in human smooth muscle cells from internal thoracic artery". American Journal of Physiology. Heart and Circulatory Physiology 284 (6): H2325–34. Jun 2003. doi:10.1152/ajpheart.00559.2002. PMID 12598232.
- "Nuclear immunostaining in rat neuronal cells using two anti-Kir2.2 ion channel polyclonal antibodies". Journal of Molecular Neuroscience 20 (2): 189–94. Apr 2003. doi:10.1385/JMN:20:2:189. PMID 12794312.
- "A multiprotein trafficking complex composed of SAP97, CASK, Veli, and Mint1 is associated with inward rectifier Kir2 potassium channels". The Journal of Biological Chemistry 279 (18): 19051–63. Apr 2004. doi:10.1074/jbc.M400284200. PMID 14960569.
- "Protein trafficking and anchoring complexes revealed by proteomic analysis of inward rectifier potassium channel (Kir2.x)-associated proteins". The Journal of Biological Chemistry 279 (21): 22331–46. May 2004. doi:10.1074/jbc.M400285200. PMID 15024025.
- "Functional expression of Kir2.x in human aortic endothelial cells: the dominant role of Kir2.2". American Journal of Physiology. Cell Physiology 289 (5): C1134–44. Nov 2005. doi:10.1152/ajpcell.00077.2005. PMID 15958527.
- "Regulation of cardiac inwardly rectifying potassium current IK1 and Kir2.x channels by endothelin-1". Journal of Molecular Medicine 84 (1): 46–56. Jan 2006. doi:10.1007/s00109-005-0707-8. PMID 16258766.
External links
- Kir2.2+channel at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
![]() | Original source: https://en.wikipedia.org/wiki/KCNJ12.
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