Biology:CLIC6
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Chloride intracellular channel protein 6 is a protein that in humans is encoded by the CLIC6 gene.[1][2]
The CLIC6 gene encodes a member of the chloride intracellular channel family of proteins. The gene is part of a large triplicated region found on chromosomes 1, 6, and 21. An alternatively spliced transcript variant has been described, but its biological validity has not been determined.[2]
Interactions
CLIC6 has been shown to interact with Dopamine receptor D3.[3]
Function
CLIC6 has been shown to form chloride selective redox and pH regulated ion channels. It is predominantly expressed in the plasma membrane of lung epithelial cells.[4]
See also
References
- ↑ "The DNA sequence of human chromosome 21". Nature 405 (6784): 311–319. May 2000. doi:10.1038/35012518. PMID 10830953. Bibcode: 2000Natur.405..311H.
- ↑ 2.0 2.1 "Entrez Gene: CLIC6 chloride intracellular channel 6". https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=54102.
- ↑ "CLIC6, a member of the intracellular chloride channel family, interacts with dopamine D(2)-like receptors". Brain Research. Molecular Brain Research 117 (1): 47–57. September 2003. doi:10.1016/S0169-328X(03)00283-3. PMID 14499480.
- ↑ "Biophysical characterization of chloride intracellular channel 6 (CLIC6)". The Journal of Biological Chemistry 299 (11). November 2023. doi:10.1016/j.jbc.2023.105349. PMID 37838179.
Further reading
- "Two decades with dimorphic Chloride Intracellular Channels (CLICs)". FEBS Letters 584 (10): 2112–2121. May 2010. doi:10.1016/j.febslet.2010.03.013. PMID 20226783. Bibcode: 2010FEBSL.584.2112S.
- "Segmental paralogy in the human genome: a large-scale triplication on 1p, 6p, and 21q". Mammalian Genome 13 (8): 456–462. August 2002. doi:10.1007/s00335-001-2157-0. PMID 12226712.
- "Humoral immunity to human breast cancer: antigen definition and quantitative analysis of mRNA expression". Cancer Immunity 1: 4. March 2001. PMID 12747765.
- "CLIC6, a member of the intracellular chloride channel family, interacts with dopamine D(2)-like receptors". Brain Research. Molecular Brain Research 117 (1): 47–57. September 2003. doi:10.1016/S0169-328X(03)00283-3. PMID 14499480.
- "Identification of a novel member of the CLIC family, CLIC6, mapping to 21q22.12". Gene 320: 31–40. November 2003. doi:10.1016/S0378-1119(03)00830-8. PMID 14597386.
External links
- CLIC6+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
- Human CLIC6 genome location and CLIC6 gene details page in the UCSC Genome Browser.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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