Biology:CACNA2D2

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Voltage-dependent calcium channel subunit alpha2delta-2 is a protein that in humans is encoded by the CACNA2D2 gene.

This gene encodes a member of the alpha-2/delta subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these subunits exist, either expressed from similar genes or the result of alternative splicing. Research on a highly similar protein in rabbit suggests the protein described in this record is cleaved into alpha-2 and delta subunits. Alternate transcriptional splice variants of this gene, encoding different isoforms, have been characterized.

CACNA2D2 containing channels are blocked by amiodarone.

See also

• Voltage-dependent calcium channel

Further reading

• "The ducky2J mutation in Cacna2d2 results in reduced spontaneous Purkinje cell activity and altered gene expression". J. Neurosci. 26 (48): 12576–86. 2006. doi:10.1523/JNEUROSCI.3080-06.2006. PMID 17135419. 
• "CACNA2D2-mediated apoptosis in NSCLC cells is associated with alterations of the intracellular calcium signaling and disruption of mitochondria membrane integrity". Oncogene 22 (4): 615–26. 2003. doi:10.1038/sj.onc.1206134. PMID 12555074. 
• "Identification of a single nucleotide polymorphism in the human alpha 2 delta 2 calcium channel subunit gene". Mol. Cell. Probes 15 (6): 391–3. 2002. doi:10.1006/mcpr.2001.0382. PMID 11851383. 
• "A G-to-A single nucleotide polymorphism in intron 2 of the human CACNA2D2 gene that maps at 3p21.3". Mol. Cell. Probes 15 (2): 125–7. 2001. doi:10.1006/mcpr.2000.0341. PMID 11292331. 
• "The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3: identification and evaluation of the resident candidate tumor suppressor genes. The International Lung Cancer Chromosome 3p21.3 Tumor Suppressor Gene Consortium". Cancer Res. 60 (21): 6116–33. 2000. PMID 11085536. 
• "Functional properties of a new voltage-dependent calcium channel alpha(2)delta auxiliary subunit gene (CACNA2D2)". J. Biol. Chem. 275 (16): 12237–42. 2000. doi:10.1074/jbc.275.16.12237. PMID 10766861. 
• "Neuronal distribution and functional characterization of the calcium channel alpha2delta-2 subunit". Eur. J. Neurosci. 12 (4): 1217–26. 2000. doi:10.1046/j.1460-9568.2000.01009.x. PMID 10762351. 
• "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (1): 31–9. 1998. doi:10.1093/dnares/5.1.31. PMID 9628581. 

External links

• CACNA2D2+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
• Human CACNA2D2 genome location and CACNA2D2 gene details page in the UCSC Genome Browser.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.