Biology:ITPR2

Short description: Protein-coding gene in humans

Generic protein structure example

Inositol 1,4,5-trisphosphate receptor, type 2, also known as ITPR2, is a protein which in humans is encoded by the ITPR2 gene. The protein encoded by this gene is both a receptor for inositol triphosphate and a calcium channel.

See also

• Inositol trisphosphate receptor

Further reading

• "Functional relevance of the de novo coupling between hTRPC1 and type II IP3 receptor in store-operated Ca2+ entry in human platelets.". Cell. Signal. 20 (4): 737–47. 2008. doi:10.1016/j.cellsig.2007.12.010. PMID 18249094. 
• "Postural changes in blood pressure associated with interactions between candidate genes for chronic respiratory diseases and exposure to particulate matter.". Environ. Health Perspect. 117 (6): 935–40. 2009. doi:10.1289/ehp.0800279. PMID 19590686. 
• "Activation of store-mediated calcium entry by secretion-like coupling between the inositol 1,4,5-trisphosphate receptor type II and human transient receptor potential (hTrp1) channels in human platelets.". Biochem. J. 356 (Pt 1): 191–8. 2001. doi:10.1042/0264-6021:3560191. PMID 11336651. 
• "ITPR2 as a susceptibility gene in sporadic amyotrophic lateral sclerosis: a genome-wide association study.". Lancet Neurology 6 (10): 869–77. 2007. doi:10.1016/S1474-4422(07)70222-3. PMID 17827064. 
• "Increased InsP3Rs in the junctional sarcoplasmic reticulum augment Ca2+ transients and arrhythmias associated with cardiac hypertrophy.". Proc. Natl. Acad. Sci. U.S.A. 106 (27): 11406–11. 2009. doi:10.1073/pnas.0905485106. PMID 19549843. Bibcode: 2009PNAS..10611406H. 
• "Coupling between inositol 1,4,5-trisphosphate receptors and human transient receptor potential channel 1 when intracellular Ca2+ stores are depleted.". Biochem. J. 350 Pt 3 (3): 631–5. 2000. doi:10.1042/0264-6021:3500631. PMID 10970773. 
• "Molecular genetics of successful smoking cessation: convergent genome-wide association study results.". Arch. Gen. Psychiatry 65 (6): 683–93. 2008. doi:10.1001/archpsyc.65.6.683. PMID 18519826. 
• "A two-stage genome-wide association study of sporadic amyotrophic lateral sclerosis.". Hum. Mol. Genet. 18 (8): 1524–32. 2009. doi:10.1093/hmg/ddp059. PMID 19193627. 
• "Inositol 1,4,5-trisphosphate receptors are autoantibody target antigens in patients with Sjögren's syndrome and other systemic rheumatic diseases.". Mod Rheumatol 17 (2): 137–43. 2007. doi:10.1007/s10165-006-0555-6. PMID 17437169. 
• "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. 2006. doi:10.1101/gr.4039406. PMID 16344560. 
• "Alternative splice variants of hTrp4 differentially interact with the C-terminal portion of the inositol 1,4,5-trisphosphate receptors.". FEBS Lett. 487 (3): 377–83. 2001. doi:10.1016/S0014-5793(00)02362-0. PMID 11163362. 
• "Selective down-regulation of IP(3)receptor subtypes by caspases and calpain during TNF alpha -induced apoptosis of human T-lymphoma cells.". Cell Calcium 27 (6): 315–28. 2000. doi:10.1054/ceca.2000.0126. PMID 11013462. 
• "Release of calcium from inositol 1,4,5-trisphosphate receptor-regulated stores by HIV-1 Tat regulates TNF-alpha production in human macrophages.". J. Immunol. 164 (12): 6538–42. 2000. doi:10.4049/jimmunol.164.12.6538. PMID 10843712. 
• "Evidence that type I, II, and III inositol 1,4,5-trisphosphate receptors can occur as integral plasma membrane proteins.". J. Biol. Chem. 275 (35): 27488–93. 2000. doi:10.1074/jbc.M004495200. PMID 10874040. 
• "Hypoxia differently modulates gene expression of inositol 1,4,5-trisphosphate receptors in mouse kidney and HEK 293 cell line.". Ann. N. Y. Acad. Sci. 1148 (1): 421–7. 2008. doi:10.1196/annals.1410.034. PMID 19120137. Bibcode: 2008NYASA1148..421J. 
• "Phosphorylation of inositol 1,4,5-trisphosphate receptors in parotid acinar cells. A mechanism for the synergistic effects of cAMP on Ca2+ signaling.". J. Biol. Chem. 277 (2): 1340–8. 2002. doi:10.1074/jbc.M106609200. PMID 11694504. 
• "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.". Genome Res. 14 (9): 1711–8. 2004. doi:10.1101/gr.2435604. PMID 15342556. 
• "Selective coupling of type 6 adenylyl cyclase with type 2 IP3 receptors mediates direct sensitization of IP3 receptors by cAMP.". J. Cell Biol. 183 (2): 297–311. 2008. doi:10.1083/jcb.200803172. PMID 18936250. 
• "Genome-wide survey of human alternative pre-mRNA splicing with exon junction microarrays.". Science 302 (5653): 2141–4. 2003. doi:10.1126/science.1090100. PMID 14684825. Bibcode: 2003Sci...302.2141J. 

External links

• ITPR2+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)