Biology:KCNJ8

Short description: Protein-coding gene in humans

Generic protein structure example

Potassium inwardly-rectifying channel, subfamily J, member 8, also known as KCNJ8, is a human gene encoding the K_ir6.1 protein. A mutation in KCNJ8 has been associated with cardiac arrest in the early repolarization syndrome.

Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. K_ir6.1 is an integral membrane protein and inward-rectifier type potassium channel. K_ir6.1, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins.

See also

• Inward-rectifier potassium ion channel

Further reading

• Kubo Y; Adelman JP; Clapham DE et al. (2006). "International Union of Pharmacology. LIV. Nomenclature and molecular relationships of inwardly rectifying potassium channels". Pharmacol. Rev. 57 (4): 509–526. doi:10.1124/pr.57.4.11. PMID 16382105. 
• Inagaki N; Tsuura Y; Namba N et al. (1995). "Cloning and functional characterization of a novel ATP-sensitive potassium channel ubiquitously expressed in rat tissues, including pancreatic islets, pituitary, skeletal muscle, and heart". J. Biol. Chem. 270 (11): 5691–5694. doi:10.1074/jbc.270.11.5691. PMID 7890693. 
• "cDNA sequence, gene structure, and chromosomal localization of the human ATP-sensitive potassium channel, uKATP-1, gene (KCNJ8)". Genomics 30 (1): 102–104. 1996. doi:10.1006/geno.1995.0018. PMID 8595887. 
• Suzuki M; Kotake K; Fujikura K et al. (1998). "Kir6.1: a possible subunit of ATP-sensitive K+ channels in mitochondria". Biochem. Biophys. Res. Commun. 241 (3): 693–697. doi:10.1006/bbrc.1997.7891. PMID 9434770. 
• "Genomic organization and expression of KCNJ8/Kir6.1, a gene encoding a subunit of an ATP-sensitive potassium channel". Gene 211 (1): 71–78. 1998. doi:10.1016/S0378-1119(98)00086-9. PMID 9573340. 
• Surah-Narwal S; Xu SZ; McHugh D et al. (1999). "Block of human aorta Kir6.1 by the vascular KATP channel inhibitor U37883A". Br. J. Pharmacol. 128 (3): 667–672. doi:10.1038/sj.bjp.0702862. PMID 10516647. 
• "Mapping of the physical interaction between the intracellular domains of an inwardly rectifying potassium channel, Kir6.2". J. Biol. Chem. 274 (47): 33393–33397. 1999. doi:10.1074/jbc.274.47.33393. PMID 10559219. 
• Kono Y; Horie M; Takano M et al. (2001). "The properties of the Kir6.1-6.2 tandem channel co-expressed with SUR2A". Pflügers Arch. 440 (5): 692–698. doi:10.1007/s004240000315. PMID 11007308. 
• "A mechanism for ATP-sensitive potassium channel diversity: Functional coassembly of two pore-forming subunits". Proc. Natl. Acad. Sci. U.S.A. 98 (2): 729–734. 2001. doi:10.1073/pnas.011370498. PMID 11136227. 
• Liu Y; Ren G; O'Rourke B et al. (2001). "Pharmacological comparison of native mitochondrial K(ATP) channels with molecularly defined surface K(ATP) channels". Mol. Pharmacol. 59 (2): 225–30. doi:10.1124/mol.59.2.225. PMID 11160857. 
• "Assembly limits the pharmacological complexity of ATP-sensitive potassium channels". J. Biol. Chem. 277 (16): 13717–13723. 2002. doi:10.1074/jbc.M112209200. PMID 11825905. 
• Vanoye CG; MacGregor GG; Dong K et al. (2002). "The carboxyl termini of K(ATP) channels bind nucleotides". J. Biol. Chem. 277 (26): 23260–23270. doi:10.1074/jbc.M112004200. PMID 11956191. 
• Miki T; Suzuki M; Shibasaki T et al. (2002). "Mouse model of Prinzmetal angina by disruption of the inward rectifier Kir6.1". Nat. Med. 8 (5): 466–472. doi:10.1038/nm0502-466. PMID 11984590. 
• "Protein kinase G activates inwardly rectifying K(+) channel in cultured human proximal tubule cells". Am. J. Physiol. Renal Physiol. 283 (4): F784–91. 2002. doi:10.1152/ajprenal.00023.2002. PMID 12217870. 
• Curley M; Cairns MT; Friel AM et al. (2003). "Expression of mRNA transcripts for ATP-sensitive potassium channels in human myometrium". Mol. Hum. Reprod. 8 (10): 941–945. doi:10.1093/molehr/8.10.941. PMID 12356945. 
• Strausberg RL; Feingold EA; Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M. 
• Singh H; Hudman D; Lawrence CL et al. (2004). "Distribution of Kir6.0 and SUR2 ATP-sensitive potassium channel subunits in isolated ventricular myocytes". J. Mol. Cell. Cardiol. 35 (5): 445–459. doi:10.1016/S0022-2828(03)00041-5. PMID 12738227. https://figshare.com/articles/journal_contribution/10078208. 
• Insuk SO; Chae MR; Choi JW et al. (2003). "Molecular basis and characteristics of KATP channel in human corporal smooth muscle cells". Int. J. Impot. Res. 15 (4): 258–266. doi:10.1038/sj.ijir.3901013. PMID 12934053. 
• Emanuele E; Falcone C; Carabela M et al. (2004). "Absence of Kir6.1/KCNJ8 mutations in Italian patients with abnormal coronary vasomotion". Int. J. Mol. Med. 12 (4): 509–12. doi:10.3892/ijmm.12.4.509. PMID 12964027. 
• Gerhard DS; Wagner L; Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMID 15489334. 

External links

• KCNJ8+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.