Biology:KCNK1
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Potassium channel subfamily K member 1 is a protein that in humans is encoded by the KCNK1 gene.[1][2][3]
This gene encodes K2P1.1, a member of the superfamily of potassium channel proteins containing two pore-forming P domains. The product of this gene has not been shown to be a functional channel, however, and it may require other non-pore-forming proteins for activity.[3]
See also
- Tandem pore domain potassium channel
References
- ↑ "Assignment of the human weak inward rectifier K+ channel TWIK-1 gene to chromosome 1q42-q43". Genomics 34 (1): 153–5. Dec 1996. doi:10.1006/geno.1996.0259. PMID 8661042.
- ↑ "International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels". Pharmacol Rev 57 (4): 527–40. Dec 2005. doi:10.1124/pr.57.4.12. PMID 16382106. https://escholarship.org/uc/item/3k15p5vt.
- ↑ 3.0 3.1 "Entrez Gene: KCNK1 potassium channel, subfamily K, member 1". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3775.
Further reading
- "Sequence and function of the two P domain potassium channels: implications of an emerging superfamily". J. Mol. Med. 76 (1): 13–20. 1998. doi:10.1007/s109-1998-8100-0. PMID 9462864.
- "Molecular and functional properties of two-pore-domain potassium channels". Am. J. Physiol. Renal Physiol. 279 (5): F793–801. 2000. doi:10.1152/ajprenal.2000.279.5.F793. PMID 11053038.
- "Potassium leak channels and the KCNK family of two-P-domain subunits". Nat. Rev. Neurosci. 2 (3): 175–84. 2001. doi:10.1038/35058574. PMID 11256078. https://escholarship.org/uc/item/9z7112ns.
- Lesage F; Guillemare E; Fink M et al. (1996). "TWIK-1, a ubiquitous human weakly inward rectifying K+ channel with a novel structure". EMBO J. 15 (5): 1004–11. doi:10.1002/j.1460-2075.1996.tb00437.x. PMID 8605869.
- Lesage F; Reyes R; Fink M et al. (1997). "Dimerization of TWIK-1 K+ channel subunits via a disulfide bridge". EMBO J. 15 (23): 6400–7. doi:10.1002/j.1460-2075.1996.tb01031.x. PMID 8978667.
- Orias M; Velázquez H; Tung F et al. (1997). "Cloning and localization of a double-pore K channel, KCNK1: exclusive expression in distal nephron segments". Am. J. Physiol. 273 (4 Pt 2): F663–6. doi:10.1152/ajprenal.1997.273.4.F663. PMID 9362344.
- Wang Z; Yue L; White M et al. (1999). "Differential distribution of inward rectifier potassium channel transcripts in human atrium versus ventricle". Circulation 98 (22): 2422–8. doi:10.1161/01.cir.98.22.2422. PMID 9832487.
- Medhurst AD; Rennie G; Chapman CG et al. (2001). "Distribution analysis of human two pore domain potassium channels in tissues of the central nervous system and periphery". Brain Res. Mol. Brain Res. 86 (1–2): 101–14. doi:10.1016/S0169-328X(00)00263-1. PMID 11165377.
- Strausberg RL; Feingold EA; Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Cellular localization of TWIK-1, a two-pore-domain potassium channel in the rodent inner ear". Hear. Res. 181 (1–2): 20–6. 2004. doi:10.1016/S0378-5955(03)00162-X. PMID 12855359.
- Ota T; Suzuki Y; Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Gerhard DS; Wagner L; Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
- Rajan S; Plant LD; Rabin ML et al. (2005). "Sumoylation silences the plasma membrane leak K+ channel K2P1". Cell 121 (1): 37–47. doi:10.1016/j.cell.2005.01.019. PMID 15820677. https://escholarship.org/uc/item/8dq3t9rr.
- Rual JF; Venkatesan K; Hao T et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R.
External links
- KCNK1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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