Biology:KCNMB4
 Generic protein structure example |
Calcium-activated potassium channel subunit beta-4 is a protein that in humans is encoded by the KCNMB4 gene.[1][2][3]
MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the modulatory beta subunit. The protein encoded by this gene is an auxiliary beta subunit which slows activation kinetics, leads to steeper calcium sensitivity, and shifts the voltage range of current activation to more negative potentials than does the beta 1 subunit.[3]
See also
References
- ↑ "Cloning and functional characterization of novel large conductance calcium-activated potassium channel beta subunits, hKCNMB3 and hKCNMB4". J Biol Chem 275 (9): 6453–61. Apr 2000. doi:10.1074/jbc.275.9.6453. PMID 10692449.
- ↑ "hKCNMB3 and hKCNMB4, cloning and characterization of two members of the large-conductance calcium-activated potassium channel beta subunit family". FEBS Lett 474 (1): 99–106. Jul 2000. doi:10.1016/S0014-5793(00)01584-2. PMID 10828459.
- ↑ 3.0 3.1 "Entrez Gene: KCNMB4 potassium large conductance calcium-activated channel, subfamily M, beta member 4". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27345.
Further reading
- "New disguises for an old channel: MaxiK channel beta-subunits.". News Physiol. Sci. 17 (4): 156–61. 2002. doi:10.1152/nips.01387.2002. PMID 12136044.
- "HIV-1 gp120 and chemokines activate ion channels in primary macrophages through CCR5 and CXCR4 stimulation". Proc. Natl. Acad. Sci. U.S.A. 97 (9): 4832–7. 2000. doi:10.1073/pnas.090521697. PMID 10758170. Bibcode: 2000PNAS...97.4832L.
- "A neuronal β subunit (KCNMB4) makes the large conductance, voltage- and Ca2+-activated K+ channel resistant to charybdotoxin and iberiotoxin". Proc. Natl. Acad. Sci. U.S.A. 97 (10): 5562–7. 2000. doi:10.1073/pnas.100118597. PMID 10792058. Bibcode: 2000PNAS...97.5562M.
- "A novel nervous system beta subunit that downregulates human large conductance calcium-dependent potassium channels". J. Neurosci. 20 (10): 3563–70. 2000. doi:10.1523/JNEUROSCI.20-10-03563.2000. PMID 10804197.
- "Phosphorylation-dependent functional coupling of hSlo calcium-dependent potassium channel and its hbeta 4 subunit". J. Biol. Chem. 277 (12): 10014–20. 2002. doi:10.1074/jbc.M107682200. PMID 11790768.
- "Reciprocal modulation between the alpha and beta 4 subunits of hSlo calcium-dependent potassium channels". J. Biol. Chem. 277 (46): 43724–9. 2003. doi:10.1074/jbc.M205795200. PMID 12223479.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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