Biology:TPCN2
 Generic protein structure example |
Two pore segment channel 2 (TPC2) is a protein which in humans is encoded by the TPCN2 gene.[1] TPC2 is an ion channel, however, in contrast to other calcium and sodium channels which have four homologous domains, each containing 6 transmembrane segments (S1 to S6), TPCN1 only contains two domain (each containing segments S1 to S6).[2]
Structure
TPC2 is homologous to TPC1, the best characterized member of the TPC family. The structure of a TPC1 ortholog from Arabidopsis thaliana has been solved by two laboratories.[3][4] The structures were solved using X-ray crystallography and contained the fold of a voltage-gated ion channel and EF hands.
Filoviral Infections
Genetic knockout and pharmacological inhibition experiments demonstrate that Two-pore Channels, TPC1 and TPC2, are required for infection by Filoviruses Ebola and Marburg in mice.[5]
See also
References
- ↑ "Entrez Gene: two pore segment channel 2". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=219931.
- ↑ "International Union of Pharmacology. L. Nomenclature and structure-function relationships of CatSper and two-pore channels". Pharmacological Reviews 57 (4): 451–4. December 2005. doi:10.1124/pr.57.4.7. PMID 16382101.
- ↑ "Structure of the voltage-gated two-pore channel TPC1 from Arabidopsis thaliana". Nature 531 (7593): 196–201. March 2016. doi:10.1038/nature16446. PMID 26689363. Bibcode: 2016Natur.531..196G.
- ↑ "Structure, inhibition and regulation of two-pore channel TPC1 from Arabidopsis thaliana". Nature 531 (7593): 258–62. March 2016. doi:10.1038/nature17194. PMID 26961658. Bibcode: 2016Natur.531..258K.
- ↑ "Ebola virus. Two-pore channels control Ebola virus host cell entry and are drug targets for disease treatment". Science 347 (6225): 995–8. February 2015. doi:10.1126/science.1258758. PMID 25722412.
Further reading
- "Two newly identified genetic determinants of pigmentation in Europeans". Nature Genetics 40 (7): 835–7. July 2008. doi:10.1038/ng.160. PMID 18488028.
- "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Research 14 (9): 1711–8. September 2004. doi:10.1101/gr.2435604. PMID 15342556.
- "NAADP mobilizes calcium from acidic organelles through two-pore channels". Nature 459 (7246): 596–600. May 2009. doi:10.1038/nature08030. PMID 19387438. Bibcode: 2009Natur.459..596C.
- "Human chromosome 11 DNA sequence and analysis including novel gene identification". Nature 440 (7083): 497–500. March 2006. doi:10.1038/nature04632. PMID 16554811. Bibcode: 2006Natur.440..497T.
- "Circular rapid amplification of cDNA ends for high-throughput extension cloning of partial genes". Genomics 84 (1): 205–10. July 2004. doi:10.1016/j.ygeno.2004.01.011. PMID 15203218.
External links
- TPCN2+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
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