Biology:SCN2B

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Sodium channel subunit beta-2 is a protein that in humans is encoded by the SCN2B gene.

See also

• Sodium channel

Further reading

• "The sodium channel from rat brain. Purification and subunit composition.". J. Biol. Chem. 259 (3): 1667–75. 1984. doi:10.1016/S0021-9258(17)43460-0. PMID 6319405. 
• "Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence.". Nature 377 (6547 Suppl): 3–174. 1995. PMID 7566098. http://www.columbia.edu/itc/biology/pollack/w4065/client_edit/readings/nature377_3.pdf. 
• "Structure and function of the beta 2 subunit of brain sodium channels, a transmembrane glycoprotein with a CAM motif". Cell 83 (3): 433–42. 1996. doi:10.1016/0092-8674(95)90121-3. PMID 8521473. 
• "Structure and chromosomal localization of the beta2 subunit of the human brain sodium channel". NeuroReport 8 (12): 2775–9. 1997. doi:10.1097/00001756-199708180-00025. PMID 9295116. 
• "Exclusion of the SCN2B gene as candidate for CMT4B". Eur. J. Hum. Genet. 6 (6): 629–34. 1999. doi:10.1038/sj.ejhg.5200220. PMID 9887383. 
• "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M. 
• "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. 2003. doi:10.1101/gr.1293003. PMID 12975309. 
• "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039. 
• "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334. 
• "Presenilin/gamma-secretase-mediated cleavage of the voltage-gated sodium channel beta2-subunit regulates cell adhesion and migration". J. Biol. Chem. 280 (24): 23251–61. 2005. doi:10.1074/jbc.M412938200. PMID 15833746. 

External links

• SCN2B+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
• Overview of all the structural information available in the PDB for UniProt: O60939 (Sodium channel subunit beta-2) at the PDBe-KB.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.