Biology:Aquaporin 3
 Generic protein structure example |
Aquaporin 3 is the protein product of the human AQP3 gene.[1] It is found in the basolateral cell membrane of principal collecting duct cells and provides a pathway for water to exit these cells.[2] Aquaporin 3 is also permeable to glycerol, ammonia, urea, and hydrogen peroxide. It is expressed in various tissues including the skin, respiratory tract, and kidneys as well as various types of cancers.[3] In the kidney, aquaproin 3 is unresponsive to vasopressin (a.k.a. Antidiuretic Hormone), unlike Aquaporin 2.[4] This protein is also a determinant for the GIL blood group system.[5]
Suberoylanilide hydroxamic acid (SAHA) (a HDAC inhibitor) increases expression of aquaporin-3 in normal skin cells (keratinocytes).[6]
Clinical significance
Aquaporin 3 levels are often lower in psoriasis than in healthy skin.[6]
Aquaporin 3 is expressed more in atopic eczema.[7]
Recent studies indicate that aquaporin 3 is overexpressed in many types of malignancies such as melanoma[3] and primary effusion lymphomas[8] as well as cancers of the lung, colon, stomach, esophagus, mouth, liver, and pancreatic duct.[1][8] Based on these as well as cell culture studies, it is suggested that this overexpression contributes to the growth and spread of at least some of these cancers and therefore may be a therapeutic target for the treatment of these cancers.[1][3][8]
See also
References
- ↑ 1.0 1.1 1.2 "Aquaporin-3 in Cancer". International Journal of Molecular Sciences 18 (10): 2106. October 2017. doi:10.3390/ijms18102106. PMID 28991174.
- ↑ "Aquaporin-2 and -3: representatives of two subgroups of the aquaporin family colocalized in the kidney collecting duct". Annu. Rev. Physiol. 60: 199–220. 1998. doi:10.1146/annurev.physiol.60.1.199. PMID 9558461.
- ↑ 3.0 3.1 3.2 "Emergent Nanotechnological Strategies for Systemic Chemotherapy against Melanoma". Nanomaterials 9 (10): 1455. October 2019. doi:10.3390/nano9101455. PMID 31614947.
- ↑ "Aquaporins (Water Channels): Role in Vasopressin-Activated Water Transport". Proc. Soc. Exp. Biol. Med. 219 (3): 183–99. 1998. doi:10.3181/00379727-219-44332. PMID 9824541.
- ↑ "AQP3 deficiency in humans and the molecular basis of a novel blood group system, GIL". J. Biol. Chem. 277 (48): 45854–9. 2002. doi:10.1074/jbc.M208999200. PMID 12239222.
- ↑ 6.0 6.1 Cancer therapy shows promise for psoriasis treatment
- ↑ "Increased expression of aquaporin 3 in atopic eczema.". Allergy 61 (9): 1132–7. 2006. doi:10.1111/j.1398-9995.2006.01151.x. PMID 16918518.
- ↑ 8.0 8.1 8.2 "Biology and management of primary effusion lymphoma". Blood 132 (18): 1879–1888. November 2018. doi:10.1182/blood-2018-03-791426. PMID 30154110.
Further reading
- "Recruitment of human aquaporin 3 to internal membranes in the Plasmodium falciparum infected erythrocyte.". Mol. Biochem. Parasitol. 167 (1): 48–53. 2009. doi:10.1016/j.molbiopara.2009.04.006. PMID 19393693.
- "Genetic conservation of the GIL blood group determining aquaporin 3 gene in African and Caucasian populations.". Transfusion 48 (6): 1164–8. 2008. doi:10.1111/j.1537-2995.2008.01683.x. PMID 18435676.
- "Aquaporin 3 expression in human fetal membranes and its up-regulation by cyclic adenosine monophosphate in amnion epithelial cell culture.". J. Soc. Gynecol. Investig. 13 (3): 181–5. 2006. doi:10.1016/j.jsgi.2006.02.002. PMID 16638588.
- "Upregulation of AQP3 and AQP5 induced by dexamethasone and ambroxol in A549 cells.". Respiratory Physiology & Neurobiology 161 (2): 111–8. 2008. doi:10.1016/j.resp.2007.12.007. PMID 18280225.
- "Membrane trafficking of aquaporin 3 induced by epinephrine.". Biochem. Biophys. Res. Commun. 373 (4): 613–7. 2008. doi:10.1016/j.bbrc.2008.06.086. PMID 18601899.
- "Tumor necrosis factor-alpha decreases aquaporin-3 expression in DJM-1 keratinocytes.". Biochem. Biophys. Res. Commun. 387 (3): 564–8. 2009. doi:10.1016/j.bbrc.2009.07.077. PMID 19619514.
- "Retinoic acid increases aquaporin 3 expression in normal human skin.". J. Invest. Dermatol. 128 (3): 542–8. 2008. doi:10.1038/sj.jid.5701047. PMID 17943189.
- "Compartmentalization of aquaporins in the human intestine.". Int J Environ Res Public Health 5 (2): 115–9. 2008. doi:10.3390/ijerph5020115. PMID 18678926.
- "Enhanced expression of multidrug resistance-associated protein 2 and reduced expression of aquaglyceroporin 3 in an arsenic-resistant human cell line.". J. Biol. Chem. 281 (27): 18401–7. 2006. doi:10.1074/jbc.M601266200. PMID 16672223.
- "Aquaporin-3 facilitates epidermal cell migration and proliferation during wound healing.". J. Mol. Med. 86 (2): 221–31. 2008. doi:10.1007/s00109-007-0272-4. PMID 17968524.
- "The expression of differentiation markers in aquaporin-3 deficient epidermis.". Arch. Dermatol. Res. 301 (3): 245–52. 2009. doi:10.1007/s00403-009-0927-9. PMID 19184071.
- "Expression of aquaporin 3 in the human prostate.". Int. J. Urol. 14 (12): 1088–92; discussion 1092. 2007. doi:10.1111/j.1442-2042.2007.01901.x. PMID 18036046.
- "Transcriptional regulation of aquaporin 3 by insulin.". J. Cell. Biochem. 102 (4): 1051–8. 2007. doi:10.1002/jcb.21350. PMID 17471492.
- "The role of water channel aquaporin 3 in the mechanism of TNF-alpha-mediated proinflammatory events: Implication in periodontal inflammation.". J. Cell. Physiol. 217 (2): 338–49. 2008. doi:10.1002/jcp.21506. PMID 18543247.
- "Aquaporin expression in the human intervertebral disc.". J. Mol. Histol. 39 (3): 303–9. 2008. doi:10.1007/s10735-008-9166-1. PMID 18247144.
- "Aquaporin-3 expression in human fetal airway epithelial progenitor cells.". Stem Cells 23 (7): 992–1001. 2005. doi:10.1634/stemcells.2004-0197. PMID 16043462.
- "Roles of aquaporin-3 water channels in volume-regulatory water flow in a human epithelial cell line.". J. Membr. Biol. 208 (1): 55–64. 2005. doi:10.1007/s00232-005-0819-7. PMID 16596446.
- "Expression of aquaporin 3 (AQP3) in normal and neoplastic lung tissues.". Hum. Pathol. 38 (1): 171–8. 2007. doi:10.1016/j.humpath.2006.07.015. PMID 17056099.
External links
- GIL blood group system at BGMUT Blood Group Antigen Gene Mutation Database at NCBI, NIH
- Human AQP3 genome location and AQP3 gene details page in the UCSC Genome Browser.
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