Biology:KCNJ14

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Potassium inwardly-rectifying channel, subfamily J, member 14 (KCNJ14), also known as K_ir2.4, is a human gene.

Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel, and probably has a role in controlling the excitability of motor neurons. Two transcript variants encoding the same protein have been found for this gene.

See also

• Inward-rectifier potassium ion channel

Further reading

• "International Union of Pharmacology. LIV. Nomenclature and molecular relationships of inwardly rectifying potassium channels". Pharmacol. Rev. 57 (4): 509–26. 2006. doi:10.1124/pr.57.4.11. PMID 16382105. 
• "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. 1997. doi:10.1101/gr.6.9.791. PMID 8889548. 
• "Kir2.4: a novel K+ inward rectifier channel associated with motoneurons of cranial nerve nuclei". J. Neurosci. 18 (11): 4096–105. 1998. doi:10.1523/JNEUROSCI.18-11-04096.1998. PMID 9592090. 
• "Cloning, structure and assignment to chromosome 19q13 of the human Kir2.4 inwardly rectifying potassium channel gene (KCNJ14)". Mamm. Genome 11 (3): 247–9. 2000. doi:10.1007/s003350010047. PMID 10723734. 
• "Cloning and functional expression of human retinal kir2.4, a pH-sensitive inwardly rectifying K(+) channel". Am. J. Physiol., Cell Physiol. 279 (3): C771–84. 2000. doi:10.1152/ajpcell.2000.279.3.C771. PMID 10942728. 
• "Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins". DNA Res. 8 (6): 319–27. 2002. doi:10.1093/dnares/8.6.319. PMID 11853319. 
• "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M. 
• "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334. 
• "Functional expression of Kir2.x in human aortic endothelial cells: the dominant role of Kir2.2". Am. J. Physiol., Cell Physiol. 289 (5): C1134–44. 2005. doi:10.1152/ajpcell.00077.2005. PMID 15958527. 
• "Functional expression of inward rectifier potassium channels in cultured human pulmonary smooth muscle cells: evidence for a major role of Kir2.4 subunits". J. Membr. Biol. 213 (1): 19–29. 2007. doi:10.1007/s00232-006-0037-y. PMID 17347781. 

External links

• KCNJ14+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.