Biology:HCN1

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Short description: Protein-coding gene in the species Homo sapiens


A representation of the 3D structure of the protein myoglobin showing turquoise α-helices.
Generic protein structure example

Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 is a protein that in humans is encoded by the HCN1 gene.[1][2][3][4]

Function

Hyperpolarization-activated cation channels of the HCN gene family, such as HCN1, contribute to spontaneous rhythmic activity in both heart and brain.[4]

Tissue distribution

HCN1 channel expression is found in the sinoatrial node,[5][6] the neocortex, hippocampus, cerebellar cortex, dorsal root ganglion, trigeminal ganglion and brainstem.[7][8][9][10][11]

Ligands

Interactions

HCN1 has been shown to interact with HCN2.[16][17]

Epilepsy

De novo mutations in HCN1 cause epilepsy.[18]

See also

  • Cyclic nucleotide-gated ion channel

References

  1. ↑ "Interactive cloning with the SH3 domain of N-src identifies a new brain specific ion channel protein, with homology to eag and cyclic nucleotide-gated channels". Proceedings of the National Academy of Sciences of the United States of America 94 (26): 14815–14820. December 1997. doi:10.1073/pnas.94.26.14815. PMID 9405696. Bibcode: 1997PNAS...9414815S. 
  2. ↑ "Identification of a gene encoding a hyperpolarization-activated pacemaker channel of brain". Cell 93 (5): 717–729. May 1998. doi:10.1016/S0092-8674(00)81434-8. PMID 9630217. 
  3. ↑ "International Union of Pharmacology. LI. Nomenclature and structure-function relationships of cyclic nucleotide-regulated channels". Pharmacological Reviews 57 (4): 455–462. December 2005. doi:10.1124/pr.57.4.8. PMID 16382102. 
  4. ↑ 4.0 4.1 "Entrez Gene: HCN1 hyperpolarization activated cyclic nucleotide-gated potassium channel 1". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=348980. 
  5. ↑ "Specific pattern of ionic channel gene expression associated with pacemaker activity in the mouse heart". The Journal of Physiology 562 (Pt 1): 223–234. January 2005. doi:10.1113/jphysiol.2004.074047. PMID 15498808. 
  6. ↑ "Distribution and prevalence of hyperpolarization-activated cation channel (HCN) mRNA expression in cardiac tissues". Circulation Research 85 (1): e1–e6. July 1999. doi:10.1161/01.RES.85.1.e1. PMID 10400919. 
  7. ↑ "Polarized and compartment-dependent distribution of HCN1 in pyramidal cell dendrites". Nature Neuroscience 5 (11): 1185–1193. November 2002. doi:10.1038/nn962. PMID 12389030. 
  8. ↑ "HCN1 ion channel immunoreactivity in spinal cord and medulla oblongata". Brain Research 1081 (1): 79–91. April 2006. doi:10.1016/j.brainres.2006.01.019. PMID 16503331. 
  9. ↑ "Differential distribution of four hyperpolarization-activated cation channels in mouse brain". Biological Chemistry 380 (7–8): 975–980. 1999. doi:10.1515/BC.1999.121. PMID 10494850. 
  10. ↑ "Hyperpolarization-activated channels in trigeminal ganglia innervating healthy and pulp-exposed teeth". International Endodontic Journal 40 (9): 715–721. September 2007. doi:10.1111/j.1365-2591.2007.01297.x. PMID 17645513. 
  11. ↑ "Interactive cloning with the SH3 domain of N-src identifies a new brain specific ion channel protein, with homology to eag and cyclic nucleotide-gated channels". Proceedings of the National Academy of Sciences of the United States of America 94 (26): 14815–14820. December 1997. doi:10.1073/pnas.94.26.14815. PMID 9405696. Bibcode: 1997PNAS...9414815S. 
  12. ↑ "HCN1 channel subunits are a molecular substrate for hypnotic actions of ketamine". The Journal of Neuroscience 29 (3): 600–609. January 2009. doi:10.1523/JNEUROSCI.3481-08.2009. PMID 19158287. 
  13. ↑ "Forebrain HCN1 channels contribute to hypnotic actions of ketamine". Anesthesiology 118 (4): 785–795. April 2013. doi:10.1097/ALN.0b013e318287b7c8. PMID 23377220. 
  14. ↑ "Ketamine, Propofol, and the EEG: A Neural Field Analysis of HCN1-Mediated Interactions". Frontiers in Computational Neuroscience 7: 22. 2013. doi:10.3389/fncom.2013.00022. PMID 23576979. 
  15. ↑ "HCN1 Channels Contribute to the Effects of Amnesia and Hypnosis but not Immobility of Volatile Anesthetics". Anesthesia and Analgesia 121 (3): 661–666. September 2015. doi:10.1213/ANE.0000000000000830. PMID 26287296. 
  16. ↑ "Role of subunit heteromerization and N-linked glycosylation in the formation of functional hyperpolarization-activated cyclic nucleotide-gated channels". The Journal of Biological Chemistry 278 (44): 43781–43786. October 2003. doi:10.1074/jbc.M306958200. PMID 12928435. 
  17. ↑ "Different roles for the cyclic nucleotide binding domain and amino terminus in assembly and expression of hyperpolarization-activated, cyclic nucleotide-gated channels". The Journal of Biological Chemistry 277 (33): 29634–29642. August 2002. doi:10.1074/jbc.M200504200. PMID 12034718. 
  18. ↑ "De novo mutations in HCN1 cause early infantile epileptic encephalopathy". Nature Genetics 46 (6): 640–645. June 2014. doi:10.1038/ng.2952. PMID 24747641. https://hal.univ-lorraine.fr/hal-01710614/file/RASTETTER_Agn%C3%A8s.pdf. 

Further reading

External links

  • HCN1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
  • Overview of all the structural information available in the PDB for UniProt: O60741 (Human Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1) at the PDBe-KB.
  • Overview of all the structural information available in the PDB for UniProt: O88704 (Mouse Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1) at the PDBe-KB.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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