Biology:KCND1

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Potassium voltage-gated channel, Shal-related subfamily, member 1 (KCND1), also known as K_v4.1, is a human gene.

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shal-related subfamily, members of which form voltage-activated A-type potassium ion channels and are prominent in the repolarization phase of the action potential. This gene is expressed at moderate levels in all tissues analyzed, with lower levels in skeletal muscle.

See also

• Voltage-gated potassium channel

Further reading

• "International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels.". Pharmacol. Rev. 57 (4): 473–508. 2006. doi:10.1124/pr.57.4.10. PMID 16382104. 
• "Neuronal interleukin-16 (NIL-16): a dual function PDZ domain protein.". J. Neurosci. 19 (18): 7770–80. 1999. doi:10.1523/JNEUROSCI.19-18-07770.1999. PMID 10479680. 
• "Gene structures and expression profiles of three human KCND (Kv4) potassium channels mediating A-type currents I(TO) and I(SA).". Genomics 64 (2): 144–54. 2000. doi:10.1006/geno.2000.6117. PMID 10729221. 
• "Different effects of the Ca(2+)-binding protein, KChIP1, on two Kv4 subfamily members, Kv4.1 and Kv4.2.". FEBS Lett. 499 (3): 205–9. 2001. doi:10.1016/S0014-5793(01)02560-1. PMID 11423117. 
• "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M. 
• "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039. 
• "Modulation of Kv4.2 channel expression and gating by dipeptidyl peptidase 10 (DPP10).". Biophys. J. 87 (4): 2380–96. 2005. doi:10.1529/biophysj.104.042358. PMID 15454437. 
• "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334. 
• "A novel mechanism for the suppression of a voltage-gated potassium channel by glucose-dependent insulinotropic polypeptide: protein kinase A-dependent endocytosis.". J. Biol. Chem. 280 (31): 28692–700. 2005. doi:10.1074/jbc.M504913200. PMID 15955806. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.